Q9UBN4 | TRPC4_HUMAN | Short transient receptor potential channel 4 (TRPC4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00023 | Ank - Ankyrin repeat | 144~168 | |
| PF00520 | Ion_trans - Ion transport protein | 374~631 | |
| PF08344 | TRP_2 - Transient receptor ion channel II | 176~238 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 39~118 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4466522 |  |
IC50 | = | 0.34 | nM | 524.88 | Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(OC(F)(F)F)c1)n2Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL4377064 | cell-based format |
| CHEMBL4546097 |  |
IC50 | = | 46.0 | nM | 475.33 | Cn1c(=O)n(CCCO)c(=O)c2c1nc(Oc1cccc(Cl)c1)n2Cc1ccc(Cl)cc1 | Homo sapiens | CHEMBL4377070 | cell-based format |
| CHEMBL5201831 |  |
IC50 | = | 65.0 | nM | 442.76 | O=C1NC(=O)C(N2CCc3c(ncnc3Oc3ccc(F)cc3C(F)(F)F)C2)=C1Cl | Homo sapiens | CHEMBL5145640 | cell-based format |
| CHEMBL4530872 |  |
IC50 | = | 290.0 | nM | 386.76 | O=C1CN(c2cn[nH]c(=O)c2Cl)CCN1Cc1ccccc1C(F)(F)F | Homo sapiens | CHEMBL4410992 | cell-based format |