Q9UBF8 | PI4KB_HUMAN | Phosphatidylinositol 4-kinase beta (PI4KB)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00454 | PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase | 560~755 | |
| PF21245 | PI4KB-PIK1_PIK - PI4KB/PIK1, accessory (PIK) domain | 143~217 |
3D structures mapped by conservation among orthologs
[ Domain: "ARM repeat" // KOG0903 ]
[ Domain: "Protein kinase" // PI3_PI4_kinase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3923414 |  |
IC50 | = | 0.98 | nM | 523.02 | COc1ccc(-c2c(C)nc3c(NCCNC(C)=O)cc(Cl)nn23)cc1S(=O)(=O)N1CCOCC1 | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL3930509 |  |
IC50 | = | 2.4 | nM | 480.98 | COc1ccc(-c2c(C)nc3c(NCCNC(C)=O)cc(Cl)nn23)cc1S(=O)(=O)N(C)C | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL4205416 |  |
IC50 | = | 4.0 | nM | 462.54 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4sc(-c5cccnc5)nc34)CC2)cc1 | Homo sapiens | CHEMBL4195900 | assay format |
| CHEMBL4215340 |  |
IC50 | = | 4.0 | nM | 413.51 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4scnc34)[C@@H](C)C2)c(C)c1 | Homo sapiens | CHEMBL4195901 | assay format |
| CHEMBL4206816 |  |
IC50 | = | 5.0 | nM | 446.54 | Cc1ccc(NC(=O)N2CCN(c3nc(N)nc4sc(-c5cccnc5)nc34)CC2)cc1 | Homo sapiens | CHEMBL4195900 | assay format |
| CHEMBL3958915 |  |
IC50 | = | 5.3 | nM | 559.09 | CCc1cc(CNc2cc(Cl)nn3c(-c4ccc(OC)c(S(=O)(=O)NC(CC)CO)c4)c(C)nc23)ccn1 | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL2407818 |  |
IC50 | = | 5.7 | nM | 426.47 | Cc1nc2c(NCc3cccc(S(C)(=O)=O)c3)nccn2c1-c1ccc(O)c(F)c1 | Homo sapiens | CHEMBL2411433 | single protein format |
| CHEMBL5188324 |  |
IC50 | = | 6.1 | nM | 517.01 | CCNS(=O)(=O)c1cc(-c2c(C)nc3c(NCc4ccnc(CC)c4)cc(Cl)nn23)ccc1OO | Homo sapiens | CHEMBL5131910 | single protein format |
| CHEMBL3976651 |  |
IC50 | = | 6.1 | nM | 531.04 | CCc1cc(CNc2cc(Cl)nn3c(-c4ccc(OC)c(S(=O)(=O)NCCO)c4)c(C)nc23)ccn1 | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL3920652 |  |
IC50 | = | 6.2 | nM | 571.1 | CCc1cc(CNc2cc(Cl)nn3c(-c4ccc(OC)c(S(=O)(=O)N5CCC(O)CC5)c4)c(C)nc23)ccn1 | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL4215244 |  |
IC50 | = | 7.0 | nM | 412.52 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4sccc34)[C@@H](C)C2)c(C)c1 | Homo sapiens | CHEMBL4195901 | assay format |
| CHEMBL4203566 |  |
IC50 | = | 7.0 | nM | 413.51 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4sncc34)[C@@H](C)C2)c(C)c1 | Homo sapiens | CHEMBL4195901 | assay format |
| CHEMBL3911522 |  |
IC50 | = | 7.23 | nM | 525.03 | CCC(CO)NS(=O)(=O)c1cc(-c2c(C)nc3c(NCCNC(C)=O)cc(Cl)nn23)ccc1OC | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL1233882 |  |
IC50 | = | 8.0 | nM | 304.36 | CC(C)n1nc(-c2ccc3ncccc3c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL1243971 | single protein format |
| CHEMBL4202450 |  |
IC50 | = | 8.0 | nM | 470.99 | Cc1cc(CNc2cc(C)nc3c(-c4ccc(Cl)c(NS(C)(=O)=O)c4)c(C)nn23)ccn1 | Homo sapiens | CHEMBL4195900 | assay format |
| CHEMBL4203041 |  |
IC50 | = | 8.0 | nM | 399.48 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4scnc34)[C@@H](C)C2)cc1 | Homo sapiens | CHEMBL4195901 | assay format |
| CHEMBL3939697 |  |
IC50 | = | 8.6 | nM | 527.05 | C=CCNS(=O)(=O)c1cc(-c2c(C)nc3c(NCc4ccnc(CC)c4)cc(Cl)nn23)ccc1OC | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL3957128 |  |
IC50 | = | 9.0 | nM | 558.11 | CCc1cc(CNc2cc(Cl)nn3c(-c4ccc(OC)c(S(=O)(=O)NCCN(C)C)c4)c(C)nc23)ccn1 | Homo sapiens | CHEMBL3864066 | single protein format |
| CHEMBL4207851 |  |
IC50 | = | 9.0 | nM | 399.48 | COc1ccc(NC(=O)N2CCN(c3nc(N)nc4scnc34)CC2)c(C)c1 | Homo sapiens | CHEMBL4195901 | assay format |
| CHEMBL2165191 |  |
IC50 | = | 10.0 | nM | 408.46 | Cc1cc([C@@H](C)Nc2ccccc2C(=O)O)c2nc(N3CCOCC3)cc(=O)n2c1 | Homo sapiens | CHEMBL5468110 | single protein format |