Q9UBC3 | DNM3B_HUMAN | DNA (cytosine-5)-methyltransferase 3B (DNMT3B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00145 | DNA_methylase - C-5 cytosine-specific DNA methylase | 575~707 | |
| PF00855 | PWWP - PWWP domain | 226~309 | |
| PF17980 | ADD_DNMT3 - DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | 416~471 | |
| PF21255 | DNMT3_ADD_GATA1-like - DNMT3, ADD PHD zinc finger | 478~527 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // PWWP ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL555257 |  |
IC50 | = | 260.0 | nM | 576.68 | O=C(O)[C@@H]1C[C@H](SC[C@H]2O[C@@H](n3cnc4c(NCCc5ccc(-c6ccccc6)cc5)ncnc43)[C@H](O)[C@@H]2O)CN1 | Homo sapiens | CHEMBL1036445 | single protein format |
| CHEMBL418052 |  |
IC50 | = | 300.0 | nM | 384.42 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL557902 |  |
IC50 | = | 300.0 | nM | 396.43 | Nc1ncnc2c1ncn2[C@@H]1O[C@H](CS[C@@H]2CN[C@H](C(=O)O)C2)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL1036445 | single protein format |
| CHEMBL552309 |  |
IC50 | = | 300.0 | nM | 383.43 | Nc1ncnc2c1ccn2[C@@H]1O[C@H](CSCC[C@H](N)C(=O)O)[C@@H](O)[C@H]1O | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL5178532 |  |
IC50 | = | 300.0 | nM | 402.47 | Nc1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1CSCCCC[C@H](N)C(=O)O | Homo sapiens | CHEMBL5138548 | cell-based format |
| CHEMBL2106789 |  |
IC50 | = | 500.0 | nM | 302.28 | C[C@@H]1O[C@@H](CC(=O)O)CC2=C1C(=O)c1c(O)cccc1C2=O | Homo sapiens | CHEMBL3418014 | cell-based format |
| CHEMBL555352 |  |
IC50 | = | 600.0 | nM | 564.67 | NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCCc4ccc(-c5ccccc5)cc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL560105 |  |
IC50 | = | 600.0 | nM | 502.6 | NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCCCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL560505 |  |
IC50 | = | 900.0 | nM | 534.6 | COc1cc(CNc2ncnc3c2ncn3[C@@H]2O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]2O)cc(OC)c1 | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL1564869 |  |
IC50 | = | 900.0 | nM | 334.33 | O=C(O)[C@H](Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4606697 | cell-based format |
| CHEMBL560045 |  |
IC50 | = | 1000.0 | nM | 398.45 | Cc1nc(N)c2ncn([C@@H]3O[C@H](CSCCC(N)C(=O)O)[C@@H](O)[C@H]3O)c2n1 | Homo sapiens | CHEMBL1036409 | cell-based format |
| CHEMBL556265 |  |
IC50 | = | 1000.0 | nM | 474.54 | NC(CCSC[C@H]1O[C@@H](n2cnc3c(NCc4ccccc4)ncnc32)[C@H](O)[C@@H]1O)C(=O)O | Homo sapiens | CHEMBL1036409 | cell-based format |