Q9P2K8 | E2AK4_HUMAN | eIF-2-alpha kinase GCN2 (EIF2AK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 330~539 | |
| PF00069 | Pkinase - Protein kinase domain | 590~657 | |
| PF00069 | Pkinase - Protein kinase domain | 795~999 | |
| PF05773 | RWD - RWD domain | 21~134 | |
| PF12745 | HGTP_anticodon2 - Anticodon binding domain of tRNAs | 1396~1643 | |
| PF13393 | tRNA-synt_His - Histidyl-tRNA synthetase | 1062~1381 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5202342 |  |
IC50 | = | 3.0 | nM | 490.37 | Brc1nn(-c2ccc3ncccc3c2)c2nc(Nc3cnn(C4CCNCC4)c3)ncc12 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5427321 |  |
IC50 | = | 4.0 | nM | 347.38 | COc1ccc(-n2nnc3cnc(Nc4ccc(N)c(C)c4)nc32)cc1 | Homo sapiens | CHEMBL5348358 | single protein format |
| CHEMBL5209076 |  |
IC50 | = | 5.0 | nM | 445.92 | Clc1nn(-c2ccc3ncccc3c2)c2nc(Nc3cnn(C4CCNCC4)c3)ncc12 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL3407849 |  |
IC50 | = | 5.0 | nM | 541.61 | CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3C)cc2n1 | Homo sapiens | CHEMBL3412167 | assay format |
| CHEMBL5190023 |  |
IC50 | = | 5.0 | nM | 527.45 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)cc4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5179922 |  |
IC50 | = | 5.0 | nM | 510.4 | COCCNC(=O)[C@@H]1CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc5ncccc5c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5208600 |  |
IC50 | = | 8.0 | nM | 545.44 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(F)c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5196751 |  |
IC50 | = | 8.0 | nM | 552.46 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(C#N)c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL3407851 |  |
IC50 | = | 10.0 | nM | 562.03 | CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3Cl)cc2n1 | Homo sapiens | CHEMBL3412167 | assay format |
| CHEMBL5193210 |  |
IC50 | = | 10.0 | nM | 580.52 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(CCC#N)c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5202445 |  |
IC50 | = | 11.0 | nM | 425.5 | Cc1nn(-c2ccc3ncccc3c2)c2nc(Nc3cnn(C4CCNCC4)c3)ncc12 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL3407850 |  |
IC50 | = | 12.0 | nM | 542.6 | CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3N)cc2n1 | Homo sapiens | CHEMBL3412167 | assay format |
| CHEMBL5201930 |  |
IC50 | = | 15.0 | nM | 570.52 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(CCN)c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5170361 |  |
IC50 | = | 16.0 | nM | 511.38 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)o5)cc4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5393957 |  |
IC50 | = | 16.0 | nM | 406.45 | CCOc1ccc(-n2nnc3cnc(Nc4cnn(C5CCOCC5)c4)nc32)cc1 | Homo sapiens | CHEMBL5348357 | single protein format |
| CHEMBL5172690 |  |
IC50 | = | 16.0 | nM | 571.51 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc(-c5nnc(C)s5)c(CCO)c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5199369 |  |
IC50 | = | 17.0 | nM | 480.37 | CNC(=O)[C@]1(C)CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc5ncccc5c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5437361 |  |
IC50 | = | 18.6 | nM | 350.39 | CCOc1ccc(-n2nnc3cnc(Nc4cnn(CC)c4)nc32)cc1 | Homo sapiens | CHEMBL5348359 | single protein format |
| CHEMBL5195519 |  |
IC50 | = | 21.0 | nM | 475.35 | Brc1nn(-c2ccc3ncccc3c2)c2nc(N[C@@H]3CC[C@@H](c4ncc[nH]4)C3)ncc12 | Homo sapiens | CHEMBL5111583 | single protein format |
| CHEMBL5180017 |  |
IC50 | = | 21.0 | nM | 466.34 | CNC(=O)[C@@H]1CC[C@@H](Nc2ncc3c(Br)nn(-c4ccc5ncccc5c4)c3n2)C1 | Homo sapiens | CHEMBL5111583 | single protein format |