Q9NZQ8 | TRPM5_HUMAN | Transient receptor potential cation channel subfamily M member 5 (TRPM5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 743~986 | |
| PF18139 | LSDAT_euk - SLOG in TRPM | 39~268 | |
| PF25508 | TRPM2 - TRPM2-like domain | 367~626 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3932326 |  |
IC50 | = | 1.3 | nM | 399.88 | COc1ccc(/C=N/NC(=O)CCn2cc(Cl)c3c(C)cccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3926856 |  |
IC50 | = | 1.4 | nM | 400.48 | COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc2cccnc12 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3921169 |  |
IC50 | = | 1.8 | nM | 379.46 | COc1ccc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3984818 |  |
IC50 | = | 3.0 | nM | 397.45 | COc1cc(F)c(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3890861 |  |
IC50 | = | 5.0 | nM | 384.48 | Cc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc2cccnc12 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3920665 |  |
IC50 | = | 6.0 | nM | 395.46 | COc1ccc(/C=N/NC(=O)CCn2cc(C)c3c(OC)cccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3958181 |  |
IC50 | = | 9.0 | nM | 379.46 | COc1ccc(/C=N/NC(=O)CCc2cn(C)c3c(C)cccc23)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3917255 |  |
IC50 | = | 12.0 | nM | 365.43 | COc1ccc(/C=N/NC(=O)CCn2ccc3c(C)cccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3952275 |  |
IC50 | = | 17.0 | nM | 365.43 | COc1ccc(/C=N/NC(=O)CCn2cc(C)c3ccccc32)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3910957 |  |
IC50 | = | 24.0 | nM | 391.47 | Cc1cccc2c1c(C)cn2CCC(=O)N/N=C/c1ccc2c(c1)OCCCO2 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3965696 |  |
IC50 | = | 30.0 | nM | 370.46 | Cc1cn(CCC(=O)N/N=C/c2cc(C)c3ncccc3c2)c2ccccc12 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3918456 |  |
IC50 | = | 37.0 | nM | 392.38 | COc1ccc(/C=N/NC(=O)[C@@H]2C[C@H]2c2cccc(C(F)(F)F)c2)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3949870 |  |
IC50 | = | 38.0 | nM | 413.91 | COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)cc(Cl)c1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3954591 |  |
IC50 | = | 40.0 | nM | 364.85 | COc1ccc(/C=N/NC(=O)CSc2cccc(Cl)c2)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3964050 |  |
IC50 | = | 45.0 | nM | 379.85 | COc1cc(/C=N/NC(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2)cc2cccnc12 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3968083 |  |
IC50 | = | 46.0 | nM | 456.55 | COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1ccncc1 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3981183 |  |
IC50 | = | 51.0 | nM | 361.83 | COc1ccc(/C=N/NC(=O)NCCc2ccc(Cl)cc2)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3968112 |  |
IC50 | = | 51.0 | nM | 365.43 | COc1ccc(/C=N/NC(=O)CCc2cn(C)c3ccccc23)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3914721 |  |
IC50 | = | 53.0 | nM | 456.55 | COc1cc(/C=N/NC(=O)CCn2cc(C)c3c(C)cccc32)ccc1OCc1cccnc1 | Homo sapiens | CHEMBL3880020 | cell-based format |
| CHEMBL3980338 |  |
IC50 | = | 55.0 | nM | 378.88 | COc1ccc(/C=N/NC(=O)C(C)Sc2cccc(Cl)c2)cc1OC | Homo sapiens | CHEMBL3880020 | cell-based format |