Q9NZK7 | PA2GE_HUMAN | Group IIE secretory phospholipase A2 (PLA2G2E)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00068 | Phospholip_A2_1 - Phospholipase A2 | 21~127 |
3D structures mapped by conservation among orthologs
[ Domain: "Phospholipase A2, PLA2" // Phospholip_A2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL514692 |  |
IC50 | = | 7.0 | nM | 519.58 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL515637 |  |
IC50 | = | 7.0 | nM | 430.46 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL148649 |  |
IC50 | = | 9.0 | nM | 394.43 | CCc1c(C(=O)C(N)=O)c2c(OC(C)C(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL332993 |  |
IC50 | = | 10.0 | nM | 456.5 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL5172164 |  |
IC50 | = | 10.0 | nM | 442.47 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL5150981 | cell-based format |
| CHEMBL446349 |  |
IC50 | = | 16.0 | nM | 569.64 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL514841 |  |
IC50 | = | 20.0 | nM | 386.45 | CCc1c(C(=O)C(N)=O)c2c(OC)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL208315 |  |
IC50 | = | 50.0 | nM | 394.43 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc(C)cc2n1Cc1ccccc1 | Homo sapiens | CHEMBL862127 | single protein format |
| CHEMBL148674 |  |
IC50 | = | 50.0 | nM | 380.4 | CCc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL862127 | single protein format |
| CHEMBL346196 |  |
IC50 | = | 75.0 | nM | 366.37 | Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cccc2n1Cc1ccccc1 | Homo sapiens | CHEMBL862127 | single protein format |
| CHEMBL517821 |  |
IC50 | = | 90.0 | nM | 454.53 | CCc1c(C(=O)C(N)=O)c2c(OCC(C)=O)cccn2c1Cc1ccccc1-c1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL208429 |  |
IC50 | = | 125.0 | nM | 380.4 | Cc1cc(OCC(=O)O)c2c(C(=O)C(N)=O)c(C)n(Cc3ccccc3)c2c1 | Homo sapiens | CHEMBL862127 | single protein format |
| CHEMBL514705 |  |
IC50 | = | 260.0 | nM | 458.51 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)O)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |
| CHEMBL506485 |  |
IC50 | = | 840.0 | nM | 597.69 | CC(C)Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3ccccc3c2n1Cc1ccccc1 | Homo sapiens | CHEMBL990830 | single protein format |