Q9NZJ5 | E2AK3_HUMAN | Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 595~660 | |
| PF00069 | Pkinase - Protein kinase domain | 881~1075 |
3D structures mapped by conservation among orthologs
[ Domain: "PERK and Ire1 luminal domains" // PQQ_2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2171122 |  |
IC50 | = | 0.2 | nM | 417.9 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171144 |  |
IC50 | = | 0.2 | nM | 397.48 | Cc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)c1 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171143 |  |
IC50 | = | 0.2 | nM | 397.48 | Cc1ccccc1CC(=O)N1CCc2cc(-c3cn(C)c4ncnc(N)c34)ccc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171141 |  |
IC50 | = | 0.2 | nM | 401.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171126 |  |
IC50 | = | 0.2 | nM | 437.43 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(F)c2F)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171125 |  |
IC50 | = | 0.3 | nM | 469.44 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171124 |  |
IC50 | = | 0.4 | nM | 451.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(C(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171139 |  |
IC50 | = | 0.4 | nM | 419.44 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cc(F)ccc2F)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171123 |  |
IC50 | = | 0.5 | nM | 413.48 | COc1cccc(CC(=O)N2CCc3cc(-c4cn(C)c5ncnc(N)c45)ccc32)c1 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2441342 |  |
IC50 | = | 0.5 | nM | 470.43 | Cn1cc(-c2ccc3c(c2F)CCN3C(=O)Cc2cccc(C(F)(F)F)n2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2444392 | single protein format |
| CHEMBL2171135 |  |
IC50 | = | 0.6 | nM | 422.46 | Nc1ncnc2scc(-c3ccc4c(c3)CCN4C(=O)Cc3cc(F)ccc3F)c12 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171140 |  |
IC50 | = | 0.7 | nM | 401.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccc2F)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171131 |  |
IC50 | = | 0.9 | nM | 451.56 | Nc1ncc(-c2cn[nH]c2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171121 |  |
IC50 | = | 0.9 | nM | 417.9 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccccc2Cl)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL3407846 |  |
IC50 | = | 1.0 | nM | 469.44 | Cn1cc(-c2ccc3c(c2)CCN3CC(=O)c2cc(F)cc(C(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL3412166 | assay format |
| CHEMBL3407849 |  |
IC50 | = | 1.0 | nM | 541.61 | CNc1ncc2ccc(Oc3cc(C(=O)c4c(-c5ccccc5)n(C)n(-c5ccccc5)c4=O)ccc3C)cc2n1 | Homo sapiens | CHEMBL3412166 | assay format |
| CHEMBL2171129 |  |
IC50 | = | 1.2 | nM | 462.58 | Nc1ncc(-c2ccncc2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171142 |  |
IC50 | = | 1.5 | nM | 401.45 | Cn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2ccc(F)cc2)c2c(N)ncnc21 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL2171130 |  |
IC50 | = | 1.9 | nM | 468.63 | Nc1ncc(C2CCNCC2)c2scc(-c3ccc4c(c3)CCN4C(=O)Cc3ccccc3)c12 | Homo sapiens | CHEMBL2172956 | single protein format |
| CHEMBL3407863 |  |
IC50 | = | 2.0 | nM | 483.47 | Cc1nc(N)c2c(-c3ccc4c(c3)CCN4CC(=O)c3cc(F)cc(C(F)(F)F)c3)cn(C)c2n1 | Homo sapiens | CHEMBL3412166 | assay format |