Q9NZ45 | CISD1_HUMAN | CDGSH iron-sulfur domain-containing protein 1 (CISD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF09360 | zf-CDGSH - Iron-binding zinc finger CDGSH type | 65~87 | |
| PF10660 | MitoNEET_N - Iron-containing outer mitochondrial membrane protein N-terminus | 12~40 |
3D structures mapped by conservation among orthologs
[ Domain: "Type 1 and 2" // zf-CDGSH_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3979616 |  |
IC50 | = | 148.0 | nM | 254.24 | O=C1/C(=C\c2ccccc2O)Oc2cc(O)ccc21 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL3893332 |  |
IC50 | = | 518.0 | nM | 371.48 | COc1cc(/C=C2/SC(=S)NC2=O)ccc1OCc1ccc(C)cc1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL3970270 |  |
IC50 | = | 686.1 | nM | 383.47 | CCc1ccc(OCCCOc2ccc(/C=C3/SC(=O)NC3=O)cc2)cc1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL121 |  |
IC50 | = | 731.0 | nM | 357.44 | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL230515 |  |
IC50 | = | 770.1 | nM | 357.46 | COc1cc(/C=C2/SC(=S)NC2=O)ccc1OCc1ccccc1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL3890124 |  |
IC50 | = | 838.9 | nM | 375.83 | O=C1NC(=O)/C(=C\c2ccc(OCCOc3ccccc3Cl)cc2)S1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL496587 |  |
IC50 | = | 860.0 | nM | 284.13 | O=C1NC(=O)/C(=C/c2cccc(Br)c2)S1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL1823807 |  |
IC50 | = | 860.0 | nM | 284.13 | O=C1NC(=O)/C(=C\c2cccc(Br)c2)S1 | Homo sapiens | CHEMBL1826572 | single protein format |
| CHEMBL3948168 |  |
IC50 | = | 910.0 | nM | 281.31 | CN(C)c1ccc(/C=C2/Oc3cc(O)ccc3C2=O)cc1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL3959175 |  |
IC50 | = | 945.4 | nM | 379.87 | O=C1NC(=S)S/C1=C/c1ccc(OCc2ccc(F)cc2)c(Cl)c1 | Homo sapiens | CHEMBL3863230 | assay format |
| CHEMBL3979616 | |
Ki | = | 6.0 | nM | 254.24 | O=C1/C(=C\c2ccccc2O)Oc2cc(O)ccc21 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL3893332 | |
Ki | = | 22.0 | nM | 371.48 | COc1cc(/C=C2/SC(=S)NC2=O)ccc1OCc1ccc(C)cc1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL3970270 | |
Ki | = | 29.0 | nM | 383.47 | CCc1ccc(OCCCOc2ccc(/C=C3/SC(=O)NC3=O)cc2)cc1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL121 | |
Ki | = | 31.0 | nM | 357.44 | CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL230515 | |
Ki | = | 33.0 | nM | 357.46 | COc1cc(/C=C2/SC(=S)NC2=O)ccc1OCc1ccccc1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL3890124 | |
Ki | = | 36.0 | nM | 375.83 | O=C1NC(=O)/C(=C\c2ccc(OCCOc3ccccc3Cl)cc2)S1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL496587 | |
Ki | = | 37.0 | nM | 284.13 | O=C1NC(=O)/C(=C/c2cccc(Br)c2)S1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL3948168 | |
Ki | = | 39.0 | nM | 281.31 | CN(C)c1ccc(/C=C2/Oc3cc(O)ccc3C2=O)cc1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL3959175 | |
Ki | = | 40.0 | nM | 379.87 | O=C1NC(=S)S/C1=C/c1ccc(OCc2ccc(F)cc2)c(Cl)c1 | Homo sapiens | CHEMBL3863231 | assay format |
| CHEMBL2348829 |  |
Ki | = | 46.0 | nM | 300.2 | O=C1NC(=S)S/C1=C\c1cccc(Br)c1 | Homo sapiens | CHEMBL3863231 | assay format |