Q9NZ08 | ERAP1_HUMAN | Endoplasmic reticulum aminopeptidase 1 (ERAP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01433 | Peptidase_M1 - Peptidase family M1 domain | 281~484 | |
| PF11838 | ERAP1_C - ERAP1-like C-terminal domain | 597~916 | |
| PF17900 | Peptidase_M1_N - Peptidase M1 N-terminal domain | 60~246 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // KOG1046 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // ERAP1_C_2 ]
[ Domain: "Baculovirus p35 protein-related" // Peptidase_M1_2 ]
[ Domain: "ARM repeat" // ERAP1_C_1 ]
[ Domain: "ARM repeat" // EUF08227 ]
[ Domain: "Metalloproteases ("zincins") catalytic domain" // Peptidase_M1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3416733 |  |
IC50 | = | 33.0 | nM | 512.59 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O | Homo sapiens | CHEMBL3418219 | cell-based format |
| CHEMBL4095882 |  |
IC50 | = | 33.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccc(O)cc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4862557 |  |
IC50 | = | 34.0 | nM | 415.85 | O=C(NC1(C(=O)O)CCCCC1)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4101200 |  |
IC50 | = | 43.0 | nM | 455.5 | C#CC[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4077855 |  |
IC50 | = | 65.0 | nM | 590.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2O)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4863142 |  |
IC50 | = | 99.0 | nM | 401.82 | O=C(NC1(C(=O)O)CCCC1)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4875461 |  |
IC50 | = | 115.0 | nM | 449.87 | O=C(NC1(C(=O)O)Cc2ccccc2C1)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4864508 |  |
IC50 | = | 120.0 | nM | 397.86 | O=C(NC1(C(=O)O)CCCCC1)c1cccc2cc(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4069425 |  |
IC50 | = | 126.0 | nM | 574.62 | NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc(-c2ccccc2)no1)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4854733 |  |
IC50 | = | 140.0 | nM | 527.6 | COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CP(=O)(O)[C@@H](N)CCc1ccccc1 | Homo sapiens | CHEMBL4822042 | single protein format |
| CHEMBL4855038 |  |
IC50 | = | 151.0 | nM | 476.75 | O=C(NC1(C(=O)O)CCCCC1)c1cccc2c(Br)c(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4099693 |  |
IC50 | = | 155.0 | nM | 473.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4854530 |  |
IC50 | = | 262.0 | nM | 437.85 | O=C(N[C@H](Cc1ccccc1)C(=O)O)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4847534 |  |
IC50 | = | 275.0 | nM | 399.81 | CC(C)(NC(=O)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12)c1nnn[nH]1 | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4853049 |  |
IC50 | = | 330.0 | nM | 469.57 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)NCCc1c[nH]c2ccccc12 | Homo sapiens | CHEMBL4822042 | single protein format |
| CHEMBL4097268 |  |
IC50 | = | 340.0 | nM | 489.55 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | Homo sapiens | CHEMBL4024805 | cell-based format |
| CHEMBL4850551 |  |
IC50 | = | 377.0 | nM | 389.81 | CCC(C)(NC(=O)c1cc(F)cc2cc(-c3ccc(Cl)cc3)oc12)C(=O)O | Homo sapiens | CHEMBL4824855 | single protein format |
| CHEMBL4877339 |  |
IC50 | = | 410.0 | nM | 513.58 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL4822042 | single protein format |
| CHEMBL5194003 |  |
IC50 | = | 480.0 | nM | 540.62 | CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CCOc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O | Homo sapiens | CHEMBL5149505 | cell-based format |
| CHEMBL3827468 |  |
IC50 | = | 520.0 | nM | 326.38 | CC(C)C[C@H](CP(=O)(O)[C@@H](N)CCc1ccccc1)C(N)=O | Homo sapiens | CHEMBL3829450 | single protein format |