Q9NYY3 | PLK2_HUMAN | Serine/threonine-protein kinase PLK2 (PLK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 84~334 | |
| PF00659 | POLO_box - POLO box duplicated region | 512~566 | |
| PF00659 | POLO_box - POLO box duplicated region | 609~673 |
3D structures mapped by conservation among orthologs
[ Domain: "Polo-box domain" // POLO_box ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1094477 |  |
IC50 | = | 2.0 | nM | 334.38 | Cc1ccccc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2 | Homo sapiens | CHEMBL1109142 | single protein format |
| CHEMBL4166771 |  |
IC50 | = | 3.4 | nM | 444.56 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(S(=O)(=O)NC)cc3)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL4592698 |  |
IC50 | = | 3.98 | nM | 492.62 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCCC4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4409681 | assay format |
| CHEMBL522618 |  |
IC50 | = | 4.0 | nM | 359.39 | C[C@H](Nc1cc2c(-c3ccc4c(c3)OCO4)noc2cn1)c1ccccc1 | Homo sapiens | CHEMBL991583 | single protein format |
| CHEMBL4454222 |  |
IC50 | = | 4.72 | nM | 476.63 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCCC4)cc3C)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4409681 | assay format |
| CHEMBL4171770 |  |
IC50 | = | 4.88 | nM | 446.56 | CCNC(=O)c1ccc2c(ccn2-c2ncc3c(n2)N(C2CCCC2)[C@H](CC)C(=O)N3C)c1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL2401963 |  |
IC50 | = | 5.0 | nM | 402.5 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3ccccc3)nc2N1C1CCCC1 | Homo sapiens | CHEMBL2406852 | single protein format |
| CHEMBL5430344 |  |
IC50 | = | 5.73 | nM | 547.66 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(-c4noc(CN5CCNCC5)n4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL5361558 | single protein format |
| CHEMBL5435085 |  |
IC50 | = | 6.32 | nM | 561.69 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(-c4noc(CN5CCCNCC5)n4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL5361558 | single protein format |
| CHEMBL4175722 |  |
IC50 | = | 7.06 | nM | 486.62 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc4cc(C(=O)NC5CCCC5)ccc43)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL4176983 |  |
IC50 | = | 7.86 | nM | 474.59 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(S(=O)(=O)NCCO)cc3)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL4548940 |  |
IC50 | = | 7.98 | nM | 478.6 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCCC4)cc3O)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4409681 | assay format |
| CHEMBL2401971 |  |
IC50 | = | 8.0 | nM | 404.47 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3ccccc3)nc2N1[C@H]1CCOC1 | Homo sapiens | CHEMBL2406852 | single protein format |
| CHEMBL4169129 |  |
IC50 | = | 8.16 | nM | 488.61 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(S(=O)(=O)NCCCO)cc3)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL4163892 |  |
IC50 | = | 8.6 | nM | 432.53 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccc4cc(C(=O)NC)ccc43)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL559845 |  |
IC50 | = | 9.0 | nM | 320.36 | Cn1nc(C(N)=O)c2c1-c1nc(Nc3ccccc3)ncc1CC2 | Homo sapiens | CHEMBL1109142 | single protein format |
| CHEMBL2401966 |  |
IC50 | = | 9.0 | nM | 430.43 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3ccccc3)nc2N1CCC(F)(F)F | Homo sapiens | CHEMBL2406852 | single protein format |
| CHEMBL4168155 |  |
IC50 | = | 10.17 | nM | 430.53 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(S(N)(=O)=O)cc3)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL4164012 |  |
IC50 | = | 11.35 | nM | 460.58 | CCCNC(=O)c1ccc2c(ccn2-c2ncc3c(n2)N(C2CCCC2)[C@H](CC)C(=O)N3C)c1 | Homo sapiens | CHEMBL4143483 | assay format |
| CHEMBL2401969 |  |
IC50 | = | 12.0 | nM | 442.45 | CC[C@@H]1C(=O)N(C)c2cnc(-n3ccnc3-c3ccc(F)cc3)nc2N1C1CC(F)(F)C1 | Homo sapiens | CHEMBL2406852 | single protein format |