Q9NYW2 | TA2R8_HUMAN | Taste receptor type 2 member 8 (TAS2R8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF05296 | TAS2R - Taste receptor protein (TAS2R) | 1~304 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4112934 |  |
IC50 | = | 10.0 | nM | 379.42 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@@H](C)N(Cc3ccccc3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3939399 |  |
IC50 | = | 10.0 | nM | 427.44 | Cc1noc(C)c1Cn1cc(N2C(=O)N(Cc3ccc(F)c(O)c3)C(C)(C)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3923956 |  |
IC50 | = | 10.0 | nM | 379.42 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@H](C)N(Cc3ccccc3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3976506 |  |
IC50 | = | 10.0 | nM | 397.41 | Cc1noc(C)c1Cn1cc(N2C(=O)CN(CCc3ccc(F)cc3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3898803 |  |
IC50 | = | 10.0 | nM | 425.45 | Cc1noc(C)c1Cn1cc(N2C(=O)N(Cc3cc(O)cc(O)c3)C(C)(C)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3950223 |  |
IC50 | = | 10.0 | nM | 412.43 | Cc1noc(C)c1Cn1cc(-n2c(=O)n(C)n(CCc3ccc(F)cc3)c2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3939063 |  |
IC50 | = | 20.0 | nM | 451.48 | COc1ccc(CN2C(=O)N(c3cnn(Cc4c(C)noc4C)c3)C(=O)C23CC3)cc1OC | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3964034 |  |
IC50 | = | 20.0 | nM | 393.4 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@@H]3Cc4ccc(O)cc4CN3C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3979194 |  |
IC50 | = | 20.0 | nM | 379.42 | Cc1noc(C)c1Cn1cc(N2C(=O)C(C)N(Cc3ccccc3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3961116 |  |
IC50 | = | 20.0 | nM | 407.43 | Cc1noc(C)c1Cn1cc(N2C(=O)N(Cc3cccc(O)c3)C3(CC3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3949830 |  |
IC50 | = | 20.0 | nM | 439.47 | COc1cc(O)cc(CN2C(=O)N(c3cnn(Cc4c(C)noc4C)c3)C(=O)C2(C)C)c1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3902192 |  |
IC50 | = | 20.0 | nM | 437.46 | COc1ccc(CN2C(=O)N(c3cnn(Cc4c(C)noc4C)c3)C(=O)C23CC3)cc1O | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3933031 |  |
IC50 | = | 20.0 | nM | 395.42 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@H](C)N(Cc3cccc(O)c3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL4108527 |  |
IC50 | = | 20.0 | nM | 395.42 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@@H](C)N(Cc3cccc(O)c3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3939695 |  |
IC50 | = | 20.0 | nM | 410.43 | COCn1c(=O)n(-c2cnn(Cc3c(C)noc3C)c2)c(=O)n1Cc1ccccc1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3890262 |  |
IC50 | = | 20.0 | nM | 380.41 | Cc1noc(C)c1Cn1cc(N2C(=O)CN(Cc3ccccc3N)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3935648 |  |
IC50 | = | 20.0 | nM | 380.41 | Cc1noc(C)c1Cn1cc(-n2c(=O)n(C)n(Cc3ccccc3)c2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL4113151 |  |
IC50 | = | 30.0 | nM | 393.4 | Cc1noc(C)c1Cn1cc(N2C(=O)[C@H]3Cc4ccc(O)cc4CN3C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3970005 |  |
IC50 | = | 30.0 | nM | 421.46 | Cc1noc(C)c1Cn1cc(N2C(=O)N(Cc3cccc(O)c3)C3(CCC3)C2=O)cn1 | Homo sapiens | CHEMBL3888094 | single protein format |
| CHEMBL3911969 |  |
IC50 | = | 30.0 | nM | 435.48 | COCc1cccc(CN2C(=O)N(c3cnn(Cc4c(C)noc4C)c3)C(=O)C23CC3)c1 | Homo sapiens | CHEMBL3888094 | single protein format |