Q9NYV4 | CDK12_HUMAN | Cyclin-dependent kinase 12 (CDK12)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 729~1020 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4777061 |  |
IC50 | = | 4.0 | nM | 348.41 | N#CN1CC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)CC1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4799386 |  |
IC50 | = | 6.0 | nM | 348.41 | N#CN1CCC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4792293 |  |
IC50 | = | 9.0 | nM | 408.48 | C=CC(=O)N1CC=C(c2ccc(C(C)C(=O)Nc3cc(C4CC4)[nH]n3)cc2F)CC1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4797074 |  |
IC50 | = | 10.0 | nM | 363.42 | C=CC(=O)N1CC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4784107 |  |
IC50 | = | 12.0 | nM | 361.41 | C#CC(=O)N1CC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4852083 |  |
IC50 | = | 14.0 | nM | 466.46 | Cn1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)cn1 | Homo sapiens | CHEMBL4806301 | single protein format |
| CHEMBL4783704 |  |
IC50 | = | 14.0 | nM | 408.48 | C=CC(=O)N1CCC=C(c2ccc(C(C)C(=O)Nc3cc(C4CC4)[nH]n3)cc2F)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4847754 |  |
IC50 | = | 22.0 | nM | 467.44 | Cc1cc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)no1 | Homo sapiens | CHEMBL4806301 | single protein format |
| CHEMBL5414905 |  |
IC50 | = | 22.0 | nM | 455.51 | CCc1cnn2c(NCc3nc4ccc(F)c(F)c4[nH]3)cc(N3CCCC[C@H]3CCO)nc12 | Homo sapiens | CHEMBL5357371 | cell-based format |
| CHEMBL4211454 |  |
IC50 | = | 23.0 | nM | 480.45 | Fc1cccc(-n2cnc3c(NCc4nc5c(F)c(F)ccc5[nH]4)nc(N4CCOCC4)nc32)c1 | Homo sapiens | CHEMBL4806301 | single protein format |
| CHEMBL4791883 |  |
IC50 | = | 23.0 | nM | 377.45 | C=CC(=O)N1CCC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4781207 |  |
IC50 | = | 30.0 | nM | 391.48 | C=CC(=O)N1CCC=C(c2ccc(C(C)C(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4778676 |  |
IC50 | = | 34.0 | nM | 377.45 | C=CC(=O)N1CC=C(c2ccc(C(C)C(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4786926 |  |
IC50 | = | 37.0 | nM | 389.46 | CC#CC(=O)N1CCC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL4791767 |  |
IC50 | = | 40.0 | nM | 377.45 | C=CC(=O)N1CC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)CC1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL5198038 |  |
IC50 | = | 40.0 | nM | 421.55 | CC(C)n1cc(-c2ccnc3[nH]c(C4CCN(CC(=O)N(C)C)CC4)cc23)ccc1=O | Homo sapiens | CHEMBL5098680 | single protein format |
| CHEMBL4778572 |  |
IC50 | = | 41.0 | nM | 405.5 | C=CC(=O)N1CCC=C(c2ccc(C(CC)C(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL5179701 |  |
IC50 | = | 44.0 | nM | 532.65 | Cn1ccc(-c2ccc(N(C(=O)NCc3ccccc3)C3CCC(Nc4ccc(C#N)cn4)CC3)cc2)cc1=O | Homo sapiens | CHEMBL5109320 | single protein format |
| CHEMBL4794547 |  |
IC50 | = | 49.0 | nM | 375.43 | C#CC(=O)N1CCC=C(c2ccc(CC(=O)Nc3cc(C4CC4)[nH]n3)cn2)C1 | Homo sapiens | CHEMBL4742550 | single protein format |
| CHEMBL2103840 |  |
IC50 | = | 50.0 | nM | 396.5 | CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12 | Homo sapiens | CHEMBL5109320 | single protein format |