Q9NYL2 | M3K20_HUMAN | Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 358~407 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 17~259 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4524151 |  |
IC50 | = | 1.9 | nM | 517.91 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(Cl)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4542865 |  |
IC50 | = | 2.1 | nM | 562.36 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(Br)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4526537 |  |
IC50 | = | 2.3 | nM | 513.49 | COc1cccc(S(=O)(=O)Nc2ccc(F)c(-n3cc(-c4cnc5[nH]nc(OC)c5c4)nn3)c2F)c1 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4574656 |  |
IC50 | = | 3.0 | nM | 499.92 | COc1n[nH]c2ncc(-c3cn(-c4cccc(NS(=O)(=O)c5cccc(Cl)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4579609 |  |
IC50 | = | 3.3 | nM | 508.47 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(C#N)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4098896 |  |
IC50 | = | 3.3 | nM | 465.44 | COc1n[nH]c2ncc(C#Cc3c(F)ccc(NS(=O)(=O)c4cccc(C#N)c4)c3F)cc12 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4446003 |  |
IC50 | = | 3.8 | nM | 483.46 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5ccccc5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4450810 |  |
IC50 | = | 4.0 | nM | 559.56 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(-c6ccccc6)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4468296 |  |
IC50 | = | 4.2 | nM | 533.52 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc6ccccc56)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4096439 |  |
IC50 | = | 4.2 | nM | 474.88 | COc1n[nH]c2ncc(C#Cc3c(F)ccc(NS(=O)(=O)c4cccc(Cl)c4)c3F)cc12 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4454493 |  |
IC50 | = | 4.4 | nM | 497.49 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(C)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4448690 |  |
IC50 | = | 4.5 | nM | 533.52 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5ccc6ccccc6c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4080860 |  |
IC50 | = | 5.0 | nM | 519.33 | COc1n[nH]c2ncc(C#Cc3c(F)ccc(NS(=O)(=O)c4cccc(Br)c4)c3F)cc12 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4091071 |  |
IC50 | = | 5.1 | nM | 444.85 | O=S(=O)(Nc1ccc(F)c(C#Cc2cnc3[nH]ncc3c2)c1F)c1cccc(Cl)c1 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4104859 |  |
IC50 | = | 5.1 | nM | 474.88 | COc1n[nH]c2ncc(C#Cc3c(F)ccc(NS(=O)(=O)c4ccccc4Cl)c3F)cc12 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4457930 |  |
IC50 | = | 5.7 | nM | 499.92 | COc1n[nH]c2ncc(-c3cn(-c4cc(NS(=O)(=O)c5cccc(Cl)c5)ccc4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4449013 |  |
IC50 | = | 6.9 | nM | 525.54 | COc1n[nH]c2ncc(-c3cn(-c4c(F)ccc(NS(=O)(=O)c5cccc(C(C)C)c5)c4F)nn3)cc12 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4079935 |  |
IC50 | = | 7.5 | nM | 470.46 | COc1cccc(S(=O)(=O)Nc2ccc(F)c(C#Cc3cnc4[nH]nc(OC)c4c3)c2F)c1 | Homo sapiens | CHEMBL4055562 | cell-based format |
| CHEMBL4559022 |  |
IC50 | = | 8.9 | nM | 463.86 | Nc1ncc(-c2cn(-c3c(F)ccc(NS(=O)(=O)c4cccc(Cl)c4)c3F)nn2)cn1 | Homo sapiens | CHEMBL4355542 | cell-based format |
| CHEMBL4088739 |  |
IC50 | = | 9.6 | nM | 509.32 | COc1n[nH]c2ncc(C#Cc3c(F)ccc(NS(=O)(=O)c4cccc(Cl)c4Cl)c3F)cc12 | Homo sapiens | CHEMBL4055562 | cell-based format |