Q9NYK1 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01582 | TIR - TIR domain | 891~1016 | |
| PF13855 | LRR_8 - Leucine rich repeat | 275~324 | |
| PF13855 | LRR_8 - Leucine rich repeat | 496~554 | |
| PF13855 | LRR_8 - Leucine rich repeat | 675~735 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5079910 |  |
IC50 | = | 0.1 | nM | 383.45 | Cc1nccc(-c2cc3[nH]nc(N[C@H]4CCNC[C@@H]4F)c3cc2C2CC2)c1F | Homo sapiens | CHEMBL5050606 | cell-based format |
| CHEMBL5090067 |  |
IC50 | = | 0.39 | nM | 379.48 | Cc1nccc(-c2cc3[nH]nc(NC4CCN(C)CC4)c3cc2C2CC2)c1F | Homo sapiens | CHEMBL5050606 | cell-based format |
| CHEMBL5175791 |  |
IC50 | < | 0.5 | nM | 518.71 | CCN(C)CC(=O)NC12CCC(Cn3nc(C)c4c3CCN(c3cc(C)nc5c3cnn5C)C4)(CC1)CC2 | Homo sapiens | CHEMBL5097699 | cell-based format |
| CHEMBL4641633 |  |
IC50 | = | 0.62 | nM | 420.41 | O=c1ccc(-c2cc(C(F)(F)F)c3nn([C@H]4CCNC[C@@H]4F)cc3c2)c2n1CCC2 | Homo sapiens | CHEMBL4622224 | cell-based format |
| CHEMBL5085458 |  |
IC50 | = | 0.67 | nM | 369.44 | COc1cc2c(NC3CCN(C)CC3)n[nH]c2cc1-c1ccnc(C)c1F | Homo sapiens | CHEMBL5050606 | cell-based format |
| CHEMBL5201891 |  |
IC50 | = | 0.7 | nM | 347.51 | Cc1cc(-c2[nH]c3ccc(C4CCNCC4)cc3c2C(C)C)cc(C)n1 | Homo sapiens | CHEMBL5135990 | cell-based format |
| CHEMBL4849186 |  |
IC50 | = | 0.8 | nM | 425.54 | COc1cc(-c2cc3[nH]c4ccc(C5CCNCC5)cc4c3c(C)c2C)cn2ncnc12 | Homo sapiens | CHEMBL4828014 | cell-based format |
| CHEMBL5182126 |  |
IC50 | = | 0.8 | nM | 351.47 | Cc1cc(-c2[nH]c3cc(F)c(C4CCNCC4)cc3c2C(C)C)ccn1 | Homo sapiens | CHEMBL5135990 | cell-based format |
| CHEMBL5176097 |  |
IC50 | = | 0.9 | nM | 365.5 | Cc1cc(-c2[nH]c3ccc(C4CCNCC4)c(F)c3c2C(C)C)cc(C)n1 | Homo sapiens | CHEMBL5135990 | cell-based format |
| CHEMBL4870936 |  |
IC50 | = | 1.0 | nM | 441.56 | [2H]c1ccc2c(N3C[C@@H](C)N4Cc5nc(OC6CCNCC6)ccc5[C@H]4C3)ccc(C#N)c2n1 | Homo sapiens | CHEMBL4836652 | cell-based format |
| CHEMBL4762866 |  |
IC50 | < | 1.0 | nM | 391.52 | Cc1cc(-c2cnc(OCC34CCC(N)(CC3)CC4)c(C)c2)c2cnn(C)c2n1 | Homo sapiens | CHEMBL4727486 | tissue-based format |
| CHEMBL4790219 |  |
IC50 | < | 1.0 | nM | 393.5 | Cc1cc(-c2nn(C)c3nc(N)ncc23)cnc1OCC12CCC(N)(CC1)CC2 | Homo sapiens | CHEMBL4727486 | tissue-based format |
| CHEMBL4634860 |  |
IC50 | < | 1.0 | nM | 363.47 | Cc1cc(-c2ccnc3[nH]ncc23)cnc1OCC12CCC(N)(CC1)CC2 | Homo sapiens | CHEMBL4727486 | tissue-based format |
| CHEMBL5085289 |  |
IC50 | = | 1.0 | nM | 353.45 | Cc1cc2c(NC3CCN(C)CC3)n[nH]c2cc1-c1ccnc(C)c1F | Homo sapiens | CHEMBL5050606 | cell-based format |
| CHEMBL5435782 |  |
IC50 | = | 1.0 | nM | 516.69 | Cc1cc(N2CCc3c(c(C)nn3CC34CCC(NC(=O)CN5CCC5)(CC3)CC4)C2)c2cnn(C)c2n1 | Homo sapiens | CHEMBL5365146 | cell-based format |
| CHEMBL5077018 |  |
IC50 | = | 1.1 | nM | 379.46 | COc1cc2c(C(=O)N3CCN(C)CC3)n[nH]c2cc1-c1cc(C)nc(C)c1 | Homo sapiens | CHEMBL5050606 | cell-based format |
| CHEMBL4850118 |  |
IC50 | = | 1.3 | nM | 440.57 | [2H]c1ccc2c(N3C[C@@H](C)N4Cc5nc(N6CC[C@](C)(N)C6)ccc5[C@H]4C3)ccc(C#N)c2n1 | Homo sapiens | CHEMBL4836652 | cell-based format |
| CHEMBL4846672 |  |
IC50 | = | 1.4 | nM | 411.51 | COc1cc(-c2cc(C)c3c(c2)[nH]c2ccc(C4CCNCC4)cc23)cn2ncnc12 | Homo sapiens | CHEMBL4828014 | cell-based format |
| CHEMBL5433689 |  |
IC50 | = | 1.4 | nM | 453.59 | CCC[C@@H](C)Nc1nc(N)nc2cnn(Cc3ccc(CNC4CCOCC4)cc3OC)c12 | Homo sapiens | CHEMBL5360233 | cell-based format |
| CHEMBL4854009 |  |
IC50 | = | 1.5 | nM | 441.62 | Cc1cc(-c2cc(C)c3c(c2)[nH]c2ccc(C4CCN(CC(C)(C)O)CC4)cc23)cc(C)n1 | Homo sapiens | CHEMBL4828014 | cell-based format |