Q9NYA1 | SPHK1_HUMAN | Sphingosine kinase 1 (SPHK1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00781 | DAGK_cat - Diacylglycerol kinase catalytic domain | 16~125 |
3D structures mapped by conservation among orthologs
[ Domain: "NAD kinase beta sandwich domain-like" // KOG1116 ]
[ Domain: "Phosphofructokinase N-terminal domain" // DAGK_cat ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4066270 |  |
IC50 | = | 0.7 | nM | 379.54 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(C3CCCCC3)c2)cc1 | Homo sapiens | CHEMBL4009722 | cell-based format |
| CHEMBL4061789 |  |
IC50 | = | 2.0 | nM | 467.59 | Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3C[C@@H](O)[C@H](O)C3)cc2)c1 | Homo sapiens | CHEMBL4009721 | cell-based format |
| CHEMBL4090361 |  |
IC50 | = | 2.4 | nM | 451.59 | O=S(=O)(Cc1cccc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1)c1ccccc1 | Homo sapiens | CHEMBL4009721 | cell-based format |
| CHEMBL4077280 |  |
IC50 | = | 2.6 | nM | 451.59 | Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CC[C@H](O)C3)cc2)c1 | Homo sapiens | CHEMBL4009721 | cell-based format |
| CHEMBL2409850 |  |
IC50 | = | 3.0 | nM | 495.54 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3cc(C(F)(F)F)ccc3F)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2409847 |  |
IC50 | = | 3.0 | nM | 478.45 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccc(Cl)cc3Cl)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL4063424 |  |
IC50 | = | 3.9 | nM | 467.59 | Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3C[C@@H](O)[C@@H](O)C3)cc2)c1 | Homo sapiens | CHEMBL4009721 | cell-based format |
| CHEMBL2409849 |  |
IC50 | = | 4.0 | nM | 495.54 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccc(C(F)(F)F)cc3F)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL4086094 |  |
IC50 | = | 4.8 | nM | 339.48 | CC(C)c1cccc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1 | Homo sapiens | CHEMBL4009721 | cell-based format |
| CHEMBL2409848 |  |
IC50 | = | 5.0 | nM | 495.54 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3cccc(C(F)(F)F)c3F)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2409886 |  |
IC50 | = | 5.0 | nM | 477.55 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3cccc(C(F)(F)F)c3)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2407197 |  |
IC50 | = | 5.0 | nM | 467.68 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(C34CC5CC(CC(C5)C3)C4)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL4086161 |  |
IC50 | = | 7.0 | nM | 391.56 | Cc1nc2ccc(-c3ccc(CN4CCC[C@@H]4CO)cc3)cc2n1CCC(C)C | Homo sapiens | CHEMBL4009722 | cell-based format |
| CHEMBL2409889 |  |
IC50 | = | 7.0 | nM | 423.58 | Cc1ccc(-c2csc(Nc3ccc(CCN4CC[C@H](O)C[C@@H]4CO)cc3)n2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2409888 |  |
IC50 | = | 8.0 | nM | 444.0 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccc(Cl)cc3)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL4091588 |  |
IC50 | = | 8.0 | nM | 403.57 | Cc1nc2ccc(-c3ccc(CN4CCC[C@@H]4CO)cc3)cc2n1CCC1CCC1 | Homo sapiens | CHEMBL4009722 | cell-based format |
| CHEMBL4474024 |  |
IC50 | = | 9.0 | nM | 421.51 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3cccc(F)c3)c2)cc1 | Homo sapiens | CHEMBL4392250 | cell-based format |
| CHEMBL2407198 |  |
IC50 | = | 10.0 | nM | 415.6 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(C3CCCCC3)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2409884 |  |
IC50 | = | 10.0 | nM | 423.58 | Cc1cccc(-c2csc(Nc3ccc(CCN4CC[C@H](O)C[C@@H]4CO)cc3)n2)c1 | Homo sapiens | CHEMBL2412224 | single protein format |
| CHEMBL2409881 |  |
IC50 | = | 10.0 | nM | 444.0 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccccc3Cl)cs2)cc1 | Homo sapiens | CHEMBL2412224 | single protein format |