Q9NY59 | NSMA2_HUMAN | Sphingomyelin phosphodiesterase 3 (SMPD3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03372 | Exo_endo_phos - Endonuclease/Exonuclease/phosphatase family | 339~619 |
3D structures mapped by conservation among orthologs
[ Domain: "DNase I-like" // Exo_endo_phos ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4471834 |  |
IC50 | = | 10.0 | nM | 406.51 | CCOc1cc(-c2nc(-c3ccccc3)c(-c3cccs3)[nH]2)cc(OCC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4449307 |  |
IC50 | = | 20.0 | nM | 316.38 | COc1cc(-c2nc(-c3cccs3)c(C)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4467223 |  |
IC50 | = | 20.0 | nM | 432.48 | COc1ccc(-c2nc(-c3cc(OC)c(O)c(OC)c3)[nH]c2-c2ccc(OC)cc2)cc1 | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4551018 |  |
IC50 | = | 20.0 | nM | 310.35 | COc1cc(-c2nc(C)c(-c3ccccc3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4449305 |  |
IC50 | = | 20.0 | nM | 384.48 | COc1cc(-c2nc(-c3cccs3)c(-c3cccs3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL587104 |  |
IC50 | = | 20.0 | nM | 372.42 | COc1cc(-c2nc(-c3ccccc3)c(-c3ccccc3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL1342201 |  |
IC50 | = | 30.0 | nM | 378.45 | COc1cc(-c2nc(-c3ccccc3)c(-c3cccs3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4565746 |  |
IC50 | = | 40.0 | nM | 434.56 | CC(C)Oc1cc(-c2nc(-c3ccccc3)c(-c3cccs3)[nH]2)cc(OC(C)C)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4458407 |  |
IC50 | = | 40.0 | nM | 352.35 | COc1cc(-c2nc(-c3ccco3)c(-c3ccco3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4468906 |  |
IC50 | = | 60.0 | nM | 290.36 | CCCCc1[nH]c(-c2cc(OC)c(O)c(OC)c2)nc1C | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4577390 |  |
IC50 | = | 70.0 | nM | 296.33 | COc1cc(-c2ncc(-c3ccccc3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4588691 |  |
IC50 | = | 70.0 | nM | 400.48 | COc1cc(-c2nc(-c3ccc(C)cc3)c(-c3ccc(C)cc3)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4471548 |  |
IC50 | = | 70.0 | nM | 338.41 | COc1cc(-c2nc(-c3ccccc3)c(C(C)C)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4647644 |  |
IC50 | = | 70.0 | nM | 352.44 | COc1ccc(-c2c(C)nc3c(N4CCCC4)cc(C)nn23)cc1OC | Homo sapiens | CHEMBL4615125 | cell-based format |
| CHEMBL4533205 |  |
IC50 | = | 70.0 | nM | 514.45 | Oc1c(OCC(F)(F)F)cc(-c2nc(-c3ccccc3)c(-c3cccs3)[nH]2)cc1OCC(F)(F)F | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4634085 |  |
IC50 | = | 90.0 | nM | 521.64 | COc1ccc(-c2c(C)nc3c(N4CC[C@@H](NS(=O)(=O)c5ccc(C)cc5)C4)cc(C)nn23)cc1OC | Homo sapiens | CHEMBL4615125 | cell-based format |
| CHEMBL4514045 |  |
IC50 | = | 90.0 | nM | 304.39 | COc1cc(-c2nc(C(C)C)c(C(C)C)[nH]2)cc(OC)c1O | Homo sapiens | CHEMBL4385861 | cell-based format |
| CHEMBL4643888 |  |
IC50 | = | 100.0 | nM | 465.6 | CCCCCC(=O)N[C@@H]1CCN(c2cc(C)nn3c(-c4ccc(OC)c(OC)c4)c(C)nc23)C1 | Homo sapiens | CHEMBL4615125 | cell-based format |
| CHEMBL4635273 |  |
IC50 | = | 100.0 | nM | 513.65 | COc1ccc(-c2c(C)nc3c(N4CC[C@@H](NS(=O)(=O)c5cccs5)C4)cc(C)nn23)cc1OC | Homo sapiens | CHEMBL4615125 | cell-based format |
| CHEMBL4644091 |  |
IC50 | = | 100.0 | nM | 471.58 | COc1ccc(-c2c(C)nc3c(N4CC[C@@H](NS(=O)(=O)C5CC5)C4)cc(C)nn23)cc1OC | Homo sapiens | CHEMBL4615125 | cell-based format |