Q9NY47 | CA2D2_HUMAN | Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00092 | VWA - von Willebrand factor type A domain | 291~457 | |
| PF08399 | VWA_N - VWA N-terminal | 141~265 | |
| PF08473 | VGCC_alpha2 - Neuronal voltage-dependent calcium channel alpha 2acd | 670~1111 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1801177 |  |
IC50 | = | 10.0 | nM | 352.44 | CCOc1ccc(-n2nc3c(N4CC[C@H](N)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801206 |  |
IC50 | = | 22.0 | nM | 337.43 | CCOc1ccc(-n2nc3c(N4CCCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801207 |  |
IC50 | = | 59.0 | nM | 323.4 | CCOc1ccc(-n2nc3c(N4CCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801179 |  |
IC50 | = | 79.0 | nM | 367.45 | CCOc1ccc(-n2nc3c(N4CC[C@@H](OC)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801186 |  |
IC50 | = | 85.0 | nM | 355.42 | CCOc1ccc(-n2nc3c(N4CC[C@@H](F)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801180 |  |
IC50 | = | 126.0 | nM | 353.43 | CCOc1ccc(-n2nc3c(N4CC(OC)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801205 |  |
IC50 | = | 158.0 | nM | 311.39 | CCOc1ccc(-n2nc3c(N(C)C)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801192 |  |
IC50 | = | 200.0 | nM | 371.42 | CCOc1ccc(-n2nc3c(N4CC(OC)C4)nnc(C)c3c2C)c(F)c1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801183 |  |
IC50 | = | 316.0 | nM | 351.45 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(OC(C)C)cc3)c(C)c12 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801176 |  |
IC50 | = | 398.0 | nM | 367.45 | CCOc1ccc(-n2nc3c(N4CCC(O)CC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801182 |  |
IC50 | = | 398.0 | nM | 391.4 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(OCC(F)(F)F)cc3)c(C)c12 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801208 |  |
IC50 | = | 537.0 | nM | 297.36 | CCOc1ccc(-n2nc3c(NC)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801184 |  |
IC50 | = | 631.0 | nM | 362.26 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(Cl)cc3Cl)c(C)c12 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801188 |  |
IC50 | = | 631.0 | nM | 409.39 | Cc1nnc(N2CC[C@@H](F)C2)c2nn(-c3ccc(OCC(F)(F)F)cc3)c(C)c12 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801185 |  |
IC50 | = | 794.0 | nM | 411.82 | Cc1nnc(N2CCCC2)c2nn(-c3ccc(Cl)cc3OC(F)(F)F)c(C)c12 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801187 |  |
IC50 | = | 794.0 | nM | 373.41 | CCOc1ccc(-n2nc3c(N4CCC(F)(F)C4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801211 |  |
IC50 | = | 1000.0 | nM | 352.44 | CCOc1ccc(-n2nc3c(N4CCNCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801213 |  |
IC50 | = | 1000.0 | nM | 366.47 | CCOc1ccc(-n2nc3c(N4CCCNCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1801209 |  |
IC50 | < | 1000.0 | nM | 351.45 | CCOc1ccc(-n2nc3c(N4CCCCC4)nnc(C)c3c2C)cc1 | Homo sapiens | CHEMBL1805884 | single protein format |
| CHEMBL1059 |  |
Ki | = | 99.0 | nM | 159.23 | CC(C)C[C@H](CN)CC(=O)O | Homo sapiens | CHEMBL4714157 | cell membrane format |