Q9NY46 | SCN3A_HUMAN | Sodium channel protein type 3 subunit alpha (SCN3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 127~433 | |
| PF00520 | Ion_trans - Ion transport protein | 760~991 | |
| PF00520 | Ion_trans - Ion transport protein | 1205~1477 | |
| PF00520 | Ion_trans - Ion transport protein | 1526~1781 | |
| PF06512 | Na_trans_assoc - Sodium ion transport-associated | 998~1200 | |
| PF11933 | Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel | 558~710 | |
| PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1893~1926 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL507974 |  |
IC50 | = | 5.3 | nM | 319.27 | NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO | Homo sapiens | CHEMBL4321993 | cell-based format |
| CHEMBL4276884 |  |
IC50 | = | 11.0 | nM | 509.89 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2nccs2)c(F)c1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL501134 |  |
IC50 | = | 13.0 | nM | 299.29 | N=C1N[C@H]2[C@H](COC(N)=O)NC(=N)N3CCC(O)(O)[C@]23N1 | Homo sapiens | CHEMBL4321993 | cell-based format |
| CHEMBL4293085 |  |
IC50 | = | 13.0 | nM | 510.88 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2ncns2)c(F)c1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL3617053 |  |
IC50 | = | 17.0 | nM | 449.56 | O=C(Nc1ccc(S(=O)(=O)Nc2nccs2)cc1)C(c1ccccc1)c1ccccc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4284819 |  |
IC50 | = | 20.0 | nM | 491.9 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2nccs2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4276813 |  |
IC50 | = | 22.0 | nM | 465.86 | O=S(=O)(Nc1ncns1)c1ccc(OCc2ccc(OC(F)(F)F)c(Cl)c2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL2324354 |  |
IC50 | = | 30.0 | nM | 510.35 | O=C(NCc1ccc(Cl)c(C(F)(F)F)c1)c1ccc(S(=O)(=O)Nc2ncc(Cl)s2)cc1 | Homo sapiens | CHEMBL2328107 | single protein format |
| CHEMBL4278251 |  |
IC50 | = | 45.0 | nM | 466.38 | O=S(=O)(Nc1nccs1)c1ccc(-c2nnc(Cc3ccc(Cl)c(Cl)c3)[nH]2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4283626 |  |
IC50 | = | 124.0 | nM | 465.48 | O=S(=O)(Nc1nccs1)c1ccc(-c2nnc(Cc3ccc(C(F)(F)F)cc3)[nH]2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4290011 |  |
IC50 | = | 147.0 | nM | 441.46 | O=C(NCc1ccc(C(F)(F)F)cc1)c1ccc(S(=O)(=O)Nc2nccs2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4293390 |  |
IC50 | = | 155.0 | nM | 476.52 | O=S(=O)(CCc1ccc(C(F)(F)F)cc1)c1ccc(S(=O)(=O)Nc2nccs2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4288933 |  |
IC50 | = | 160.0 | nM | 477.51 | O=S(=O)(NCc1ccc(C(F)(F)F)cc1)c1ccc(S(=O)(=O)Nc2nccs2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4292031 |  |
IC50 | = | 197.0 | nM | 457.46 | O=C(NCc1ccc(OC(F)(F)F)cc1)c1ccc(S(=O)(=O)Nc2nccs2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4295123 |  |
IC50 | = | 237.0 | nM | 548.95 | O=C(c1ccc(OC(F)(F)F)c(Cl)c1)N1CC(OCc2ccc(S(=O)(=O)Nc3ncns3)cc2)C1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL2324411 |  |
IC50 | = | 292.0 | nM | 465.92 | Cn1nccc1-c1cc(Cl)ccc1Oc1ccc(S(=O)(=O)Nc2ncns2)cc1F | Homo sapiens | CHEMBL4040128 | cell-based format |
| CHEMBL4290885 |  |
IC50 | = | 296.0 | nM | 451.84 | O=S(=O)(Nc1ncns1)c1ccc(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL1813048 |  |
IC50 | = | 300.0 | nM | 516.52 | CC(=O)Nc1cccc(Nc2ncnc(N3CCC(OCc4ccc(OC(F)(F)F)cc4)CC3)n2)c1C | Homo sapiens | CHEMBL1816277 | cell-based format |
| CHEMBL4284536 |  |
IC50 | = | 374.0 | nM | 504.85 | O=C(NCc1ccc(OC(F)(F)F)c(Cl)c1)c1ccc(S(=O)(=O)Nc2ncccn2)c(F)c1 | Homo sapiens | CHEMBL4257698 | cell-based format |
| CHEMBL4283701 |  |
IC50 | = | 522.0 | nM | 524.91 | CN(Cc1ccc(OC(F)(F)F)c(Cl)c1)C(=O)c1ccc(S(=O)(=O)Nc2ncns2)c(F)c1 | Homo sapiens | CHEMBL4257698 | cell-based format |