Q9NXS2 | QPCTL_HUMAN | Glutaminyl-peptide cyclotransferase-like protein (QPCTL)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04389 | Peptidase_M28 - Peptidase family M28 | 150~374 |
3D structures mapped by conservation among orthologs
[ Domain: "Zn-dependent exopeptidases" // Peptidase_M28 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5089539 |  |
IC50 | = | 18.6 | nM | 521.67 | COc1cc(N(C(=O)NCCCn2cncc2C)C2CCN(C)CC2)ccc1OCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035502 | single protein format |
| CHEMBL5202172 |  |
IC50 | = | 72.0 | nM | 480.59 | COc1cc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)ccc1OCCCN1CCOCC1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5193156 |  |
IC50 | = | 73.0 | nM | 478.62 | COc1cc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)ccc1OCCCN1CCCCC1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5269831 |  |
IC50 | = | 79.6 | nM | 420.49 | Cc1n[nH]c2cc(N(Cc3ccc(F)cc3)C(=O)NCCCn3cncc3C)ccc12 | Homo sapiens | CHEMBL5249651 | single protein format |
| CHEMBL2418779 |  |
IC50 | = | 80.0 | nM | 384.49 | COc1ccc(SCc2nnc(-c3ccc4[nH]cnc4c3)s2)cc1OC | Homo sapiens | CHEMBL3887511 | single protein format |
| CHEMBL5287602 |  |
IC50 | = | 87.9 | nM | 394.52 | Cc1n[nH]c2cc(N(CC3CCCC3)C(=O)NCCCn3cncc3C)ccc12 | Homo sapiens | CHEMBL5249651 | single protein format |
| CHEMBL5204178 |  |
IC50 | = | 104.0 | nM | 325.37 | Nc1nnc(-c2ccc3c(c2)ncn3Cc2ccc(F)cc2)s1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5282127 |  |
IC50 | = | 106.1 | nM | 394.52 | Cc1n[nH]c2cc(N(C(=O)NCCCn3cncc3C)C3CCCCC3)ccc12 | Homo sapiens | CHEMBL5249651 | single protein format |
| CHEMBL5174554 |  |
IC50 | = | 152.0 | nM | 351.39 | Nc1nnc(-c2ccc3c(c2)ncn3Cc2ccc3c(c2)OCO3)s1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5195495 |  |
IC50 | = | 157.0 | nM | 332.39 | N#Cc1cccc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)c1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5202004 |  |
IC50 | = | 172.0 | nM | 343.36 | Nc1nnc(-c2ccc3c(c2)ncn3Cc2ccc(F)c(F)c2)s1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5190683 |  |
IC50 | = | 173.0 | nM | 367.43 | COc1ccc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)cc1OC | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5181839 |  |
IC50 | = | 202.0 | nM | 472.57 | COc1cc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)ccc1OCCCc1ccccn1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL5081502 |  |
IC50 | = | 213.0 | nM | 557.7 | COc1cc(N(C(=O)NCc2ccc3[nH]cnc3c2)C2CCN(C)CC2)ccc1OCCCCc1ccnc(N)c1 | Homo sapiens | CHEMBL5035502 | single protein format |
| CHEMBL5197396 |  |
IC50 | = | 219.0 | nM | 335.44 | Cc1ccc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)cc1C | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL3960080 |  |
IC50 | = | 220.0 | nM | 370.87 | COc1cccc(CCc2nnc(-c3ccc4[nH]cnc4c3)s2)c1Cl | Homo sapiens | CHEMBL3887511 | single protein format |
| CHEMBL3649518 |  |
IC50 | = | 230.0 | nM | 351.41 | Cc1cncn1CCC/N=C(\C[N+](=O)[O-])Nc1cccc2ccccc12 | Homo sapiens | CHEMBL3706344 | single protein format |
| CHEMBL5207620 |  |
IC50 | = | 239.0 | nM | 337.41 | COc1cccc(Cn2cnc3cc(-c4nnc(N)s4)ccc32)c1 | Homo sapiens | CHEMBL5149904 | single protein format |
| CHEMBL2418782 |  |
IC50 | = | 290.0 | nM | 319.37 | COc1ccc(CCn2cc(-c3ccc4[nH]cnc4c3)nn2)cc1 | Homo sapiens | CHEMBL3887511 | single protein format |
| CHEMBL5194983 |  |
IC50 | = | 297.0 | nM | 359.82 | Nc1nnc(-c2ccc3c(c2)ncn3Cc2ccc(Cl)c(F)c2)s1 | Homo sapiens | CHEMBL5149904 | single protein format |