Q9NXG6 | P4HTM_HUMAN | Transmembrane prolyl 4-hydroxylase (P4HTM)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13499 | EF-hand_7 - EF-hand domain pair | 193~251 | |
| PF13640 | 2OG-FeII_Oxy_3 - 2OG-Fe(II) oxygenase superfamily | 314~458 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3115317 |  |
IC50 | = | 70.0 | nM | 345.27 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CC(F)(F)C4)ncn3)c2=O)nn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3640646 |  |
IC50 | = | 90.0 | nM | 344.29 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CC(F)(F)C4)ncn3)c2=O)cn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3640645 |  |
IC50 | = | 130.0 | nM | 359.3 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CCC(F)(F)C4)ncn3)c2=O)nn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3642645 |  |
IC50 | = | 170.0 | nM | 339.32 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CCCCO4)ncn3)c2=O)nn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3642643 |  |
IC50 | = | 180.0 | nM | 352.36 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CCCOCC4)ncn3)c2=O)cn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3651449 |  |
IC50 | = | 180.0 | nM | 324.34 | O=c1c(-c2cccnc2)c[nH]n1-c1cc(N2CCOCC2)ncn1 | Homo sapiens | CHEMBL3705319 | single protein format |
| CHEMBL332005 |  |
IC50 | = | 185.0 | nM | 244.21 | O=C(O)c1ccc(-c2ccc(C(=O)O)cn2)nc1 | Homo sapiens | CHEMBL844877 | single protein format |
| CHEMBL3640754 |  |
IC50 | = | 260.0 | nM | 361.15 | O=C(O)c1ccc(-n2[nH]cc(-c3cncc(Br)c3)c2=O)nc1 | Homo sapiens | CHEMBL3705711 | single protein format |
| CHEMBL124527 |  |
IC50 | = | 320.0 | nM | 363.37 | CCOc1ccc(NC(=O)c2ccc(-c3ccc(C(=O)O)cn3)nc2)cc1 | Homo sapiens | CHEMBL844877 | single protein format |
| CHEMBL3642644 |  |
IC50 | = | 380.0 | nM | 353.35 | N#Cc1cn(-c2c[nH]n(-c3cc(N4CCCOCC4)ncn3)c2=O)nn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3651450 |  |
IC50 | = | 480.0 | nM | 358.79 | O=c1c(-c2ccc(Cl)nc2)c[nH]n1-c1cc(N2CCOCC2)ncn1 | Homo sapiens | CHEMBL3705319 | single protein format |
| CHEMBL3640643 |  |
IC50 | = | 540.0 | nM | 327.3 | O=C(O)C1CN(c2cc(-n3[nH]cc(-n4ccnc4)c3=O)ncn2)C1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3651451 |  |
IC50 | = | 700.0 | nM | 333.36 | Cc1cc(C)n(-c2cc(-n3[nH]cc(-c4cccnc4)c3=O)ncn2)n1 | Homo sapiens | CHEMBL3705319 | single protein format |
| CHEMBL3640644 |  |
IC50 | = | 760.0 | nM | 327.35 | CN(C)C1CN(c2cc(-n3[nH]cc(-n4ccnn4)c3=O)ncn2)C1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3640642 |  |
IC50 | = | 880.0 | nM | 367.42 | O=c1c(-n2ccnn2)c[nH]n1-c1cc(N2CCN(C3CCC3)CC2)ncn1 | Homo sapiens | CHEMBL3705129 | single protein format |
| CHEMBL3651452 |  |
IC50 | = | 880.0 | nM | 355.81 | O=c1c(-c2cccnc2)c[nH]n1-c1nnc(-c2ccc(Cl)cc2)s1 | Homo sapiens | CHEMBL3705319 | single protein format |
| CHEMBL3651453 |  |
IC50 | = | 890.0 | nM | 381.44 | COCCN1CCN(c2cc(-n3[nH]cc(-c4cccnc4)c3=O)ncn2)CC1 | Homo sapiens | CHEMBL3705319 | single protein format |
| CHEMBL3640757 |  |
IC50 | = | 900.0 | nM | 455.31 | O=C(NCc1ccnc(-n2[nH]cc(-c3cccnc3)c2=O)c1)Nc1c(Cl)cccc1Cl | Homo sapiens | CHEMBL3705711 | single protein format |
| CHEMBL3640755 |  |
IC50 | = | 910.0 | nM | 337.38 | CC(C)(C)NC(=O)c1ccc(-n2[nH]cc(-c3cccnc3)c2=O)nc1 | Homo sapiens | CHEMBL3705711 | single protein format |
| CHEMBL3651454 |  |
IC50 | = | 930.0 | nM | 239.24 | O=c1c(-c2cccnc2)c[nH]n1-c1cnccn1 | Homo sapiens | CHEMBL3705319 | single protein format |