Q9NXA8 | SIR5_HUMAN | NAD-dependent protein deacylase sirtuin-5, mitochondrial (SIRT5)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02146 | SIR2 - Sir2 family | 58~256 |
3D structures mapped by conservation among orthologs
[ Domain: "DHS-like NAD/FAD-binding domain" // SIR2_1st ]
[ Domain: "Rubredoxin-related" // SIR2_2nd_4 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL46469 |  |
IC50 | = | 100.0 | nM | 226.23 | O=C1c2c(O)cccc2Cc2cccc(O)c21 | Homo sapiens | CHEMBL4037960 | single protein format |
| CHEMBL5398650 |  |
IC50 | = | 210.0 | nM | 423.88 | CC1=NN(c2nc(-c3ccc(Cl)cc3)cs2)C(=O)/C1=C/c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL5361112 | single protein format |
| CHEMBL5416344 |  |
IC50 | = | 310.0 | nM | 582.13 | O=C(O)CCNC(=S)NCCCNc1nc(Nc2ccccc2Cl)ncc1C(=O)N1CC[C@H](c2ccccc2)C1 | Homo sapiens | CHEMBL5364471 | single protein format |
| CHEMBL5201717 |  |
IC50 | = | 390.0 | nM | 534.67 | CCCn1c(=O)c2[nH]c(SSc3nc4c([nH]3)c(=O)n(CCC)c(=O)n4CCC)nc2n(CCC)c1=O | Homo sapiens | CHEMBL5128509 | single protein format |
| CHEMBL5192844 |  |
IC50 | = | 420.0 | nM | 478.56 | CCn1c(=O)c2[nH]c(SSc3nc4c([nH]3)c(=O)n(CC)c(=O)n4CC)nc2n(CC)c1=O | Homo sapiens | CHEMBL5128509 | single protein format |
| CHEMBL4286528 |  |
IC50 | = | 450.0 | nM | 558.73 | O=C(O)CCNC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CCSc2ccccc21 | Homo sapiens | CHEMBL4256974 | single protein format |
| CHEMBL5209009 |  |
IC50 | = | 450.0 | nM | 558.73 | O=C(O)CCNC(=S)NCCCCC(NC(=O)OCc1ccccc1)C(=O)NC1CCSc2ccccc21 | Homo sapiens | CHEMBL5128508 | single protein format |
| CHEMBL5402569 |  |
IC50 | = | 520.0 | nM | 457.43 | CC1=NN(c2nc(-c3ccc(C(F)(F)F)cc3)cs2)C(=O)/C1=C/c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL5361112 | single protein format |
| CHEMBL5408550 |  |
IC50 | = | 530.0 | nM | 582.13 | O=C(O)CCNC(=S)NCCCNc1nc(Nc2ccccc2Cl)ncc1C(=O)N1CCC(c2ccccc2)C1 | Homo sapiens | CHEMBL5364471 | single protein format |
| CHEMBL5398355 |  |
IC50 | = | 580.0 | nM | 570.12 | CC[C@@H](NC(=O)c1cnc(Nc2ccccc2Cl)nc1NCCCNC(=S)NCCC(=O)O)c1ccccc1 | Homo sapiens | CHEMBL5364471 | single protein format |
| CHEMBL5424757 |  |
IC50 | = | 850.0 | nM | 407.43 | CC1=NN(c2nc(-c3ccc(F)cc3)cs2)C(=O)/C1=C/c1ccc(C(=O)O)cc1 | Homo sapiens | CHEMBL5361112 | single protein format |
| CHEMBL4290465 |  |
IC50 | = | 890.0 | nM | 502.59 | O=C(O)CCNC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1cccc(O)c1 | Homo sapiens | CHEMBL4256974 | single protein format |
| CHEMBL5197726 |  |
IC50 | = | 890.0 | nM | 502.59 | O=C(O)CCNC(=S)NCCCCC(NC(=O)OCc1ccccc1)C(=O)Nc1cccc(O)c1 | Homo sapiens | CHEMBL5128508 | single protein format |