Q9NUW8 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06087 | Tyr-DNA_phospho - Tyrosyl-DNA phosphodiesterase | 166~582 |
3D structures mapped by conservation among orthologs
[ Domain: "Phospholipase D/nuclease" // Tyr-DNA_phospho_1st ]
[ Domain: "Phospholipase D/nuclease" // Tyr-DNA_phospho_2nd ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL65 |  |
IC50 | = | 0.0 | nM | 348.36 | CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1 | Homo sapiens | CHEMBL4040006 | single protein format |
| CHEMBL4746230 |  |
IC50 | = | 10.3 | nM | 507.61 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(/C=C(\C)CCC=C(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL5187480 |  |
IC50 | = | 16.0 | nM | 551.67 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C/CC(C)CCC=C(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL5106053 | single protein format |
| CHEMBL4760174 |  |
IC50 | = | 16.4 | nM | 509.62 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(CC(C)CCC=C(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL275938 |  |
IC50 | = | 22.0 | nM | 422.35 | O=C(O)C1=CC(=C(c2ccc(O)c(C(=O)O)c2)c2ccc(O)c(C(=O)O)c2)C=CC1=O | Homo sapiens | CHEMBL4431140 | assay format |
| CHEMBL4244758 |  |
IC50 | = | 25.0 | nM | 558.63 | CC(=O)C1=C(O)C=C2Oc3c4c(c(C)c(O)c3[C@@]2(C)C1=O)O/C(=C\c1cc(C(C)(C)C)cc(C(C)(C)C)c1O)C4=O | Homo sapiens | CHEMBL4235162 | single protein format |
| CHEMBL4438274 |  |
IC50 | = | 26.0 | nM | 582.43 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C/c5ccc(Br)cc5)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4329005 | assay format |
| CHEMBL4799682 |  |
IC50 | = | 27.0 | nM | 547.63 | C=C(C)[C@H]1CC=C(/C=N\Nc2nc(-c3c(O)c(C)c(O)c4c3OC3=CC(O)=C(C(C)=O)C(=O)[C@@]34C)cs2)CC1 | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL4756604 |  |
IC50 | = | 31.0 | nM | 549.65 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C5/C[C@H]6CC[C@]5(C)C6(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL4440514 |  |
IC50 | = | 35.0 | nM | 548.53 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C/c5ccc([N+](=O)[O-])cc5)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4329005 | assay format |
| CHEMBL4761724 |  |
IC50 | = | 45.0 | nM | 547.63 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C\C5=C[C@@H]6C[C@H](C5)C6(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL4750455 |  |
IC50 | = | 46.0 | nM | 547.63 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(NN=C5C=C(C)[C@H]6C[C@@H]5C6(C)C)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL4241424 |  |
IC50 | = | 63.0 | nM | 515.34 | CC(=O)C1=C(O)C=C2Oc3c4c(c(C)c(O)c3[C@@]2(C)C1=O)O/C(=C\c1ccc(Br)s1)C4=O | Homo sapiens | CHEMBL4235162 | single protein format |
| CHEMBL4250901 |  |
IC50 | = | 64.0 | nM | 558.63 | CC(=O)C1=C(O)C=C2Oc3c4c(c(C)c(O)c3[C@]2(C)C1=O)O/C(=C\c1cc(C(C)(C)C)cc(C(C)(C)C)c1O)C4=O | Homo sapiens | CHEMBL4235162 | single protein format |
| CHEMBL4440114 |  |
IC50 | = | 68.0 | nM | 537.98 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C/c5ccc(Cl)cc5)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4329005 | assay format |
| CHEMBL4242066 |  |
IC50 | = | 81.0 | nM | 515.34 | CC(=O)C1=C(O)C=C2Oc3c4c(c(C)c(O)c3[C@]2(C)C1=O)O/C(=C\c1ccc(Br)s1)C4=O | Homo sapiens | CHEMBL4235162 | single protein format |
| CHEMBL4587610 |  |
IC50 | = | 86.0 | nM | 548.53 | CC(=O)C1=C(O)C=C2Oc3c(-c4csc(N/N=C/c5cccc([N+](=O)[O-])c5)n4)c(O)c(C)c(O)c3[C@@]2(C)C1=O | Homo sapiens | CHEMBL4329005 | assay format |
| CHEMBL4745693 |  |
IC50 | = | 88.0 | nM | 469.56 | CCCCCCc1nc(-c2c(O)c(C)c(O)c3c2OC2=CC(O)=C(C(C)=O)C(=O)[C@@]23C)cs1 | Homo sapiens | CHEMBL4669662 | assay format |
| CHEMBL4642359 |  |
IC50 | = | 99.0 | nM | 465.29 | O=c1cc(-c2cc3ccccc3oc2=O)c2ccc(OCc3c(Cl)cccc3Cl)cc2o1 | Homo sapiens | CHEMBL4614262 | single protein format |
| CHEMBL4435210 |  |
IC50 | = | 100.0 | nM | 462.72 | CC(C)c1ccc2c(c1)CC[C@H]1[C@](C)(CNC(=O)NC34CC5CC(CC(C5)C3)C4)CCC[C@]21C | Homo sapiens | CHEMBL4415210 | single protein format |