Q9NTG7 | SIR3_HUMAN | NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02146 | SIR2 - Sir2 family | 145~326 |
3D structures mapped by conservation among orthologs
[ Domain: "DHS-like NAD/FAD-binding domain" // SIR2_1st ]
[ Domain: "Rubredoxin-related" // SIR2_2nd_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2332041 |  |
IC50 | = | 3.2 | nM | 515.66 | CC(C)(C)OC(=O)c1ccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332039 |  |
IC50 | = | 4.0 | nM | 486.62 | CCNC(=O)c1ccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332037 |  |
IC50 | = | 4.9 | nM | 480.59 | CCNC(=O)c1cccc(C(=O)NCCC2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)c1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338810 |  |
IC50 | = | 7.2 | nM | 383.5 | CS(=O)(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332043 |  |
IC50 | = | 7.6 | nM | 415.54 | NC(=O)c1cc2ncnc(N3CCC(CCNC(=O)c4cccs4)CC3)c2s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332042 |  |
IC50 | = | 13.0 | nM | 459.55 | NC(=O)c1cc2ncnc(N3CCC(CCNC(=O)c4ccc(C(=O)O)s4)CC3)c2s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332040 |  |
IC50 | = | 23.0 | nM | 487.61 | CCNC(=O)c1ccc(C(=O)NCCN2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332038 |  |
IC50 | = | 24.0 | nM | 481.58 | CCNC(=O)c1cccc(C(=O)NCCN2CCN(c3ncnc4cc(C(N)=O)sc34)CC2)c1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338813 |  |
IC50 | = | 28.0 | nM | 359.5 | NC(=O)c1cc2ncnc(N3CCC(CCN4CCCC4)CC3)c2s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332044 |  |
IC50 | = | 29.0 | nM | 405.52 | CC(C)(C)OC(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338814 |  |
IC50 | = | 30.0 | nM | 360.49 | NC(=O)c1cc2ncnc(N3CCN(CCN4CCCC4)CC3)c2s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332055 |  |
IC50 | = | 33.0 | nM | 389.53 | CC(C)(C)C(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332052 |  |
IC50 | = | 39.0 | nM | 363.51 | CC(=S)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2332045 |  |
IC50 | = | 56.0 | nM | 347.44 | CC(=O)NCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338812 |  |
IC50 | = | 61.0 | nM | 345.47 | NC(=O)c1cc2ncnc(N3CCC(CN4CCCC4)CC3)c2s1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338808 |  |
IC50 | = | 67.0 | nM | 403.55 | CC(C)(C)C(=O)NCCCC1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL2338809 |  |
IC50 | = | 92.0 | nM | 390.51 | CC(C)(C)C(=O)NCCN1CCN(c2ncnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL5192844 |  |
IC50 | = | 100.0 | nM | 478.56 | CCn1c(=O)c2[nH]c(SSc3nc4c([nH]3)c(=O)n(CC)c(=O)n4CC)nc2n(CC)c1=O | Homo sapiens | CHEMBL5128518 | cell-based format |
| CHEMBL2338816 |  |
IC50 | = | 110.0 | nM | 388.54 | CC(C)(C)C(=O)NCCC1CCN(c2ccnc3cc(C(N)=O)sc23)CC1 | Homo sapiens | CHEMBL2340697 | assay format |
| CHEMBL5201717 |  |
IC50 | = | 120.0 | nM | 534.67 | CCCn1c(=O)c2[nH]c(SSc3nc4c([nH]3)c(=O)n(CCC)c(=O)n4CCC)nc2n(CCC)c1=O | Homo sapiens | CHEMBL5128518 | cell-based format |