Q9NSY1 | BMP2K_HUMAN | BMP-2-inducible protein kinase (BMP2K)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 53~311 | |
| PF15282 | BMP2K_C - BMP-2-inducible protein kinase C-terminus | 893~1161 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5188433 |  |
IC50 | = | 6.0 | nM | 392.89 | COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(Cl)c2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5184381 |  |
IC50 | = | 10.0 | nM | 372.47 | COC(=O)Nc1cc(-c2cnc(OC[C@@](C)(N)CC(C)C)c(C)c2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5202142 |  |
IC50 | = | 20.0 | nM | 408.45 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C(F)F)n2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5205578 |  |
IC50 | = | 30.0 | nM | 392.89 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5083125 |  |
IC50 | = | 38.0 | nM | 533.45 | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1 | Homo sapiens | CHEMBL5046594 | single protein format |
| CHEMBL5079149 |  |
IC50 | = | 40.0 | nM | 546.45 | NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(NC(=O)N4CCCC4)c3)ncc2Br)cc1 | Homo sapiens | CHEMBL5046594 | single protein format |
| CHEMBL5170576 |  |
IC50 | = | 90.0 | nM | 372.47 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(C)n2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL4872886 |  |
IC50 | = | 120.0 | nM | 339.34 | CC(C)C[C@@H](N)C(=O)Nc1ccc(-c2cnco2)c(OC(F)F)c1 | Homo sapiens | CHEMBL4829161 | assay format |
| CHEMBL5202351 |  |
IC50 | = | 161.0 | nM | 316.41 | CC(C)C[C@H](N)c1cc(C#N)c2cc(-c3ccncc3)ccc2n1 | Homo sapiens | CHEMBL5159151 | single protein format |
| CHEMBL4092824 |  |
IC50 | = | 180.0 | nM | 349.43 | Cc1cc(-c2cc(C(F)F)c(OC[C@@](C)(N)CC(C)C)cn2)ccn1 | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5199698 |  |
IC50 | = | 180.0 | nM | 385.4 | CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(C(F)F)c2)cc1C(F)F | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5194667 |  |
IC50 | = | 260.0 | nM | 369.84 | CC(C)C[C@](C)(N)COc1cnc(-c2ccnc(Cl)c2)cc1C(F)F | Homo sapiens | CHEMBL5161241 | single protein format |
| CHEMBL5088205 |  |
IC50 | = | 280.0 | nM | 384.42 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)F | Homo sapiens | CHEMBL5049719 | single protein format |
| CHEMBL4535040 |  |
IC50 | = | 707.0 | nM | 410.5 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CCC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345188 | cell-based format |
| CHEMBL4516665 |  |
Ki | = | 13.0 | nM | 396.47 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345184 | assay format |
| CHEMBL4535040 | |
Ki | = | 17.0 | nM | 410.5 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)C4CCC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345184 | assay format |
| CHEMBL4571548 |  |
Ki | = | 17.0 | nM | 412.52 | CC(C)CS(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345184 | assay format |
| CHEMBL4452939 |  |
Ki | = | 17.0 | nM | 427.53 | CCN(CC)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345184 | assay format |
| CHEMBL4534959 |  |
Ki | = | 17.0 | nM | 410.5 | O=C(Nc1n[nH]c2cc(-c3cccc(NS(=O)(=O)CC4CC4)c3)ccc12)C1CC1 | Homo sapiens | CHEMBL4345184 | assay format |
| CHEMBL4452360 |  |
Ki | = | 19.0 | nM | 399.48 | CN(C)S(=O)(=O)Nc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1 | Homo sapiens | CHEMBL4345184 | assay format |