Q9NRM7 | LATS2_HUMAN | Serine/threonine-protein kinase LATS2 (LATS2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 669~818 | |
| PF00069 | Pkinase - Protein kinase domain | 864~973 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 993~1042 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4592699 |  |
IC50 | = | 1.0 | nM | 319.29 | CC(Nc1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4572019 |  |
IC50 | = | 2.0 | nM | 333.32 | C[C@H](N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4577857 |  |
IC50 | = | 2.0 | nM | 345.33 | FC(F)(F)C1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 3.76 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328469 | single protein format |
| CHEMBL4551441 |  |
IC50 | = | 4.0 | nM | 279.35 | CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4585067 |  |
IC50 | = | 4.0 | nM | 280.34 | Cc1n[nH]cc1-c1nc(NC2(C)CC2)c2ccncc2n1 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4454440 |  |
IC50 | = | 4.0 | nM | 278.36 | CC(C)(C)Nc1cc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4439529 |  |
IC50 | = | 6.0 | nM | 333.32 | CC(N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4464251 |  |
IC50 | = | 8.0 | nM | 265.32 | CC(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4522021 |  |
IC50 | = | 8.0 | nM | 360.34 | FC(F)(F)C1CN(c2nc(-c3ccncc3)nc3cnccc23)CCN1 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4532021 |  |
IC50 | = | 11.0 | nM | 295.35 | CC(C)(CO)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4436873 |  |
IC50 | = | 12.0 | nM | 339.4 | CC(C)(COCCO)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4565580 |  |
IC50 | = | 15.0 | nM | 322.29 | CCCNc1nc(-c2c[nH]nc2C(F)(F)F)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4574721 |  |
IC50 | = | 15.0 | nM | 367.45 | CC(C)(O)COCC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4476180 |  |
IC50 | = | 18.0 | nM | 333.32 | C[C@@H](N(C)c1nc(-c2ccncc2)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4513243 |  |
IC50 | = | 20.0 | nM | 367.76 | CC(C)(Nc1nc(-c2ccncc2Cl)nc2cnccc12)C(F)(F)F | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4533967 |  |
IC50 | = | 21.0 | nM | 337.43 | CC(C)(O)CC(C)(C)Nc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4529548 |  |
IC50 | = | 30.0 | nM | 307.36 | OCC1(Nc2nc(-c3ccncc3)nc3cnccc23)CCC1 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4547445 |  |
IC50 | = | 30.0 | nM | 291.36 | c1cc(-c2nc(NC3CCCC3)c3ccncc3n2)ccn1 | Homo sapiens | CHEMBL4420662 | single protein format |
| CHEMBL4449036 |  |
IC50 | = | 34.0 | nM | 330.31 | FC(F)(F)C1(Nc2nc(-c3ccncc3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL4420662 | single protein format |