Q9NRA0 | SPHK2_HUMAN | Sphingosine kinase 2 (SPHK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00781 | DAGK_cat - Diacylglycerol kinase catalytic domain | 182~293 | |
| PF19279 | YegS_C - YegS C-terminal NAD kinase beta sandwich-like domain | 545~641 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4086094 |  |
IC50 | < | 1.7 | nM | 339.48 | CC(C)c1cccc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1 | Homo sapiens | CHEMBL4009723 | single protein format |
| CHEMBL4066270 |  |
IC50 | < | 1.7 | nM | 379.54 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(C3CCCCC3)c2)cc1 | Homo sapiens | CHEMBL4009723 | single protein format |
| CHEMBL5420859 |  |
IC50 | = | 1.913 | nM | 403.52 | OC[C@@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL4104017 |  |
IC50 | = | 2.4 | nM | 379.46 | Cc1nc(-c2cccc(OCc3ccc(CN4CCC[C@@H]4CO)cc3)c2)no1 | Homo sapiens | CHEMBL4009723 | single protein format |
| CHEMBL5407736 |  |
IC50 | = | 2.404 | nM | 460.41 | NC(=O)[C@H]1CCCN1C(=O)c1ccc(OCc2noc(-c3ccc(C(F)(F)F)cc3)n2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL5399307 |  |
IC50 | = | 3.431 | nM | 447.41 | O=C(c1ccc(OCc2noc(-c3ccc(C(F)(F)F)cc3)n2)cc1)N1CCC[C@@H]1CO | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL5405542 |  |
IC50 | = | 11.46 | nM | 390.44 | NC(=O)CNC(=O)c1ccc(COc2cccc(OCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL4574678 |  |
IC50 | = | 16.0 | nM | 403.52 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL4593030 |  |
IC50 | = | 17.0 | nM | 437.58 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(SCc3ccc(F)cc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL2409849 |  |
IC50 | = | 20.0 | nM | 495.54 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccc(C(F)(F)F)cc3F)cs2)cc1 | Homo sapiens | CHEMBL2412223 | single protein format |
| CHEMBL4578165 |  |
IC50 | = | 26.0 | nM | 419.59 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(SCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL4453199 |  |
IC50 | = | 31.0 | nM | 454.04 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(SCc3ccc(Cl)cc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL4472026 |  |
IC50 | = | 35.0 | nM | 401.55 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(CCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL5439990 |  |
IC50 | = | 35.78 | nM | 407.35 | O=C(NCCO)c1ccc(OCc2noc(-c3ccc(C(F)(F)F)cc3)n2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL2409848 |  |
IC50 | = | 40.0 | nM | 495.54 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3cccc(C(F)(F)F)c3F)cs2)cc1 | Homo sapiens | CHEMBL2412223 | single protein format |
| CHEMBL2409847 |  |
IC50 | = | 40.0 | nM | 478.45 | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(-c3ccc(Cl)cc3Cl)cs2)cc1 | Homo sapiens | CHEMBL2412223 | single protein format |
| CHEMBL4551657 |  |
IC50 | = | 41.0 | nM | 437.97 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccc(Cl)cc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |
| CHEMBL5433518 |  |
IC50 | = | 41.62 | nM | 376.46 | NCCNC(=O)c1ccc(COc2cccc(OCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL5432322 |  |
IC50 | = | 46.23 | nM | 376.46 | NC(=O)CNCc1ccc(COc2cccc(OCc3ccccc3)c2)cc1 | Homo sapiens | CHEMBL5366246 | single protein format |
| CHEMBL4456309 |  |
IC50 | = | 49.0 | nM | 421.51 | OC[C@H]1CCCN1Cc1ccc(COc2cccc(OCc3ccc(F)cc3)c2)cc1 | Homo sapiens | CHEMBL4392251 | cell-based format |