Q9NR96 | TLR9_HUMAN | Toll-like receptor 9 (TLR9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01582 | TIR - TIR domain | 872~996 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 123~135 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 573~588 | |
| PF13855 | LRR_8 - Leucine rich repeat | 64~97 | |
| PF13855 | LRR_8 - Leucine rich repeat | 200~254 | |
| PF13855 | LRR_8 - Leucine rich repeat | 286~344 | |
| PF13855 | LRR_8 - Leucine rich repeat | 476~510 | |
| PF13855 | LRR_8 - Leucine rich repeat | 511~555 | |
| PF13855 | LRR_8 - Leucine rich repeat | 622~665 | |
| PF13855 | LRR_8 - Leucine rich repeat | 702~762 | |
| PF18837 | LRR_12 - Leucine-rich repeat | 393~422 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3356618 |  |
IC50 | = | 3.5 | nM | 420.61 | Cc1nc(-c2ccc(N3CCN(C)CC3)cc2)nc2c1CCN2CCCN1CCCC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL3357062 |  |
IC50 | = | 3.9 | nM | 406.58 | CN1CCN(c2ccc(-c3ncc4c(n3)N(CCCN3CCCC3)CC4)cc2)CC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL2144205 |  |
IC50 | = | 4.6 | nM | 492.62 | COc1cc2nc(-c3ccc(N4CCN(C)CC4)cc3)nc(NCCN3CCOCC3)c2cc1OC | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL5169681 |  |
IC50 | = | 5.0 | nM | 545.74 | CNCc1ccc(C(=O)Nc2nc(N3CCN(C4CCCC4)CC3)c3ncn(CCCN4CCCC4)c3n2)cc1 | Homo sapiens | CHEMBL5097695 | single protein format |
| CHEMBL5094930 |  |
IC50 | = | 7.0 | nM | 545.78 | CN(C)Cc1ccc(CNc2nc(N3CCN(C4CCCC4)CC3)c3ncn(CCCN4CCCC4)c3n2)cc1 | Homo sapiens | CHEMBL5037240 | cell-based format |
| CHEMBL3357064 |  |
IC50 | = | 8.6 | nM | 422.58 | CN1CCN(c2ccc(-c3ncc4c(n3)N(CCCN3CCOCC3)CC4)cc2)CC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL3356617 |  |
IC50 | = | 11.0 | nM | 406.58 | Cc1nc(-c2ccc(N3CCN(C)CC3)cc2)nc2c1CCN2CCN1CCCC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL3357065 |  |
IC50 | = | 11.0 | nM | 436.6 | CN1CCN(c2ccc(-c3ncc4c(n3)N(CCCCN3CCOCC3)CC4)cc2)CC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL3357070 |  |
IC50 | = | 13.0 | nM | 452.6 | OCCN1CCN(c2ccc(-c3ncc4c(n3)N(CCCN3CCOCC3)CC4)cc2)CC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL5176310 |  |
IC50 | = | 15.0 | nM | 463.63 | COc1ccc(-c2nc3cc(N4CCN(C(C)C)CC4)ccn3c2CN2CCCC2)c(OC)c1 | Homo sapiens | CHEMBL5130015 | cell-based format |
| CHEMBL4065452 |  |
IC50 | = | 15.0 | nM | 449.6 | c1cc(-c2nc3ccc(OCCCN4CCCC4)cc3o2)ccc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4035077 | cell-based format |
| CHEMBL3356616 |  |
IC50 | = | 16.0 | nM | 436.6 | Cc1nc(-c2ccc(N3CCN(C)CC3)cc2)nc2c1CCN2CCCN1CCOCC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL5177422 |  |
IC50 | = | 17.0 | nM | 503.69 | COc1ccc(-c2cn3ccc(N4CCN(C5CCCC5)CC4)cc3n2)c(OCCCN2CCCC2)c1 | Homo sapiens | CHEMBL5130015 | cell-based format |
| CHEMBL5193639 |  |
IC50 | = | 19.0 | nM | 380.49 | COc1ccc(-c2cn3ccc(NCCCN4CCCC4)cc3n2)c(OC)c1 | Homo sapiens | CHEMBL5130015 | cell-based format |
| CHEMBL4282131 |  |
IC50 | = | 20.0 | nM | 537.75 | COc1cc2c(N3CCN(C4CCCC4)CC3)nc(N3CCN(C)CC3)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4269088 | cell-based format |
| CHEMBL4279467 |  |
IC50 | = | 20.0 | nM | 414.55 | COc1cc2c(N3CCNCC3)nc(N(C)C)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4269088 | cell-based format |
| CHEMBL4276673 |  |
IC50 | = | 20.0 | nM | 482.67 | COc1cc2c(N3CCN(C4CCCC4)CC3)nc(N(C)C)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4269088 | cell-based format |
| CHEMBL457704 |  |
IC50 | = | 20.0 | nM | 432.57 | CN1CCN(c2ccc(-c3nc(NCCN4CCOCC4)c4ccccc4n3)cc2)CC1 | Homo sapiens | CHEMBL5227824 | cell-based format |
| CHEMBL3356615 |  |
IC50 | = | 20.0 | nM | 422.58 | Cc1nc(-c2ccc(N3CCN(C)CC3)cc2)nc2c1CCN2CCN1CCOCC1 | Homo sapiens | CHEMBL3383964 | cell-based format |
| CHEMBL4278635 |  |
IC50 | = | 20.0 | nM | 518.66 | COc1cc2c(N3CCN(C(=O)c4ccccc4)CC3)nc(N(C)C)nc2cc1OCCCN1CCCC1 | Homo sapiens | CHEMBL4269088 | cell-based format |