Q9NR71 | ASAH2_HUMAN | Neutral ceramidase (ASAH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04734 | Ceramidase_alk - Neutral/alkaline non-lysosomal ceramidase, N-terminal | 102~608 | |
| PF17048 | Ceramidse_alk_C - Neutral/alkaline non-lysosomal ceramidase, C-terminal | 610~777 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // Ceramidse_alk_C ]
[ Domain: "Neutral ceramidase large domain" // Ceramidase_alk ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4866400 |  |
IC50 | = | 18.0 | nM | 426.69 | CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)NC(=O)NCCCCCC | Homo sapiens | CHEMBL4816193 | single protein format |
| CHEMBL4848172 |  |
Ki | = | 800.0 | nM | 471.77 | CCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](C)NC(=O)c1ccc(CCCCCCC)cc1 | Homo sapiens | CHEMBL4816179 | subcellular format |