Q9NR22 | ANM8_HUMAN | Protein arginine N-methyltransferase 8 (PRMT8)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF06325 | PrmA - Ribosomal protein L11 methyltransferase (PrmA) | 109~184 | |
| PF22528 | PRMT_C - Arginine methyltransferase oligomerization subdomain | 217~381 |
3D structures mapped by conservation among orthologs
[ Domain: "Arginine methyltransferase oligomerization subdomain" // PRMT5_C_1 ]
[ Domain: "S-adenosyl-L-methionine-dependent methyltransferases" // PrmA ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4094513 |  |
IC50 | = | 1.1 | nM | 306.86 | CN(CCN)Cc1ccccc1Sc1ccccc1Cl | Homo sapiens | CHEMBL4026505 | single protein format |
| CHEMBL3589029 |  |
IC50 | = | 2.0 | nM | 322.41 | CN(CCN)Cc1cn[nH]c1-c1ccc(Oc2ccccc2)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3901808 |  |
IC50 | = | 4.0 | nM | 287.41 | CC(C)Oc1ccc(-c2c[nH]cc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3859041 | single protein format |
| CHEMBL3589030 |  |
IC50 | = | 7.0 | nM | 322.84 | CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1Cl | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589031 |  |
IC50 | = | 10.0 | nM | 336.87 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)c(Cl)c1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589026 |  |
IC50 | = | 10.0 | nM | 288.4 | CC(C)Oc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589028 |  |
IC50 | = | 10.0 | nM | 286.42 | CC(C)Cc1ccc(-c2[nH]ncc2CN(C)CCN)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589027 |  |
IC50 | = | 14.0 | nM | 302.42 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(C)C)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589037 |  |
IC50 | = | 21.0 | nM | 438.54 | CNCCN(C)Cc1cn[nH]c1-c1cc(OCCC2CCCCC2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589033 |  |
IC50 | = | 22.0 | nM | 332.45 | CCC(CO)Oc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589032 |  |
IC50 | = | 22.0 | nM | 350.89 | CNCCN(C)Cc1cnn(C)c1-c1ccc(OC(C)C)c(Cl)c1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589036 |  |
IC50 | = | 23.0 | nM | 432.49 | CNCCN(C)Cc1cn[nH]c1-c1cc(OCCc2ccccc2)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589913 |  |
IC50 | = | 28.0 | nM | 288.4 | CCOc1ccc(-c2[nH]ncc2CN(C)CCNC)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589038 |  |
IC50 | = | 44.0 | nM | 428.5 | CNCCN(C)Cc1cn[nH]c1-c1cc(OC(CO)CC(C)C)cc(C(F)(F)F)c1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589034 |  |
IC50 | = | 55.0 | nM | 346.48 | CNCCN(C)Cc1cn[nH]c1-c1ccc(OC(CO)C(C)C)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3590417 |  |
IC50 | = | 65.0 | nM | 393.49 | CNCCN(C)Cc1n[nH]cc1-c1ccc(Oc2ccccc2C(=O)NC)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589912 |  |
IC50 | = | 67.0 | nM | 248.31 | CN(CCN)Cc1cn[nH]c1-c1ccc(F)cc1 | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL3589035 |  |
IC50 | = | 70.0 | nM | 390.84 | CC(C)Oc1c(Cl)cc(-c2c[nH]nc2CN(C)CCN)cc1C(F)(F)F | Homo sapiens | CHEMBL3591483 | assay format |
| CHEMBL4463793 |  |
IC50 | = | 110.0 | nM | 298.39 | C=CC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 | Homo sapiens | CHEMBL4346592 | single protein format |
| CHEMBL4544587 |  |
IC50 | = | 130.0 | nM | 300.41 | CCC(=O)Nc1cccc(-c2c[nH]cc2CN(C)CCN)c1 | Homo sapiens | CHEMBL4346592 | single protein format |