Q9NR20 | DYRK4_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 4 (DYRK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 104~400 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4784318 |  |
IC50 | = | 2.0 | nM | 427.51 | CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 | Homo sapiens | CHEMBL5106000 | single protein format |
| CHEMBL4873449 |  |
IC50 | = | 26.8 | nM | 319.32 | Oc1ccc(-c2n[nH]c3ncc(-c4ccc(O)c(O)c4)cc23)cc1 | Homo sapiens | CHEMBL5251373 | cell-based format |
| CHEMBL5400230 |  |
IC50 | = | 33.0 | nM | 364.47 | O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL3103192 |  |
IC50 | = | 40.0 | nM | 419.49 | CC(=O)Nc1cc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)ccc1N(C)CCN | Homo sapiens | CHEMBL3810711 | single protein format |
| CHEMBL5438158 |  |
IC50 | = | 47.0 | nM | 396.49 | O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 48.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5420645 |  |
IC50 | = | 80.0 | nM | 375.48 | Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5408907 |  |
IC50 | = | 82.0 | nM | 342.42 | CO[C@@H]1CCC[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5438293 |  |
IC50 | = | 108.0 | nM | 362.43 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5081787 |  |
IC50 | = | 108.0 | nM | 401.28 | O=C1N=C(Nc2c(Cl)cccc2Cl)S/C1=C\c1ccc2nccnc2c1 | Homo sapiens | CHEMBL5251373 | cell-based format |
| CHEMBL5091238 |  |
IC50 | = | 117.4 | nM | 378.5 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5251373 | cell-based format |
| CHEMBL5440139 |  |
IC50 | = | 121.0 | nM | 356.45 | CO[C@@H]1CCC[C@@H](NC2=N/C(=C\c3ccc4ncsc4c3)C(=O)N2)C1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5417207 |  |
IC50 | = | 127.0 | nM | 378.5 | O=C1NC(NC2C3CC4CC(C3)CC2C4)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5421442 |  |
IC50 | = | 127.0 | nM | 493.63 | CC(C)(C)NC(=O)OC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5414514 |  |
IC50 | = | 137.0 | nM | 356.45 | O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5441121 |  |
IC50 | = | 137.0 | nM | 436.37 | Cl.Cl.NC[C@@H](NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1)c1ccccc1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5396991 |  |
IC50 | = | 143.0 | nM | 362.41 | O=C1NC(NC2CCCCC2(F)F)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5422486 |  |
IC50 | = | 146.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5427842 |  |
IC50 | = | 146.0 | nM | 342.42 | CO[C@H]1CCC[C@@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363962 | single protein format |
| CHEMBL5414635 |  |
IC50 | = | 155.0 | nM | 390.47 | CO[C@@H]1Cc2ccccc2[C@H]1NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363962 | single protein format |