Q9NR19 | ACSA_HUMAN | Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00501 | AMP-binding - AMP-binding enzyme | 115~528 | |
| PF13193 | AMP-binding_C - AMP-binding enzyme C-terminal domain | 583~661 | |
| PF16177 | ACAS_N - Acetyl-coenzyme A synthetase N-terminus | 47~107 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4467131 |  |
IC50 | = | 0.0028 | nM | 500.45 | CC1=NN(c2ccc(OC(F)F)c(-c3ccncc3)c2)C(=O)C1C(=O)Nc1cccc(C(C)(F)F)c1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4873965 |  |
IC50 | = | 0.01 | nM | 497.56 | CCc1cnc(NC(=O)c2cc3c(nc2OC)nc(C(O)(c2ccccc2)c2ccccc2)n3CC)o1 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4876400 |  |
IC50 | = | 0.01 | nM | 533.54 | CCn1cnc(NC(=O)c2cc3c(nc2OC)nc(C(O)(c2ccccc2F)c2ccccc2F)n3CC)n1 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4850648 |  |
IC50 | = | 0.01 | nM | 581.56 | CCn1cnc(NC(=O)c2cc3c(nc2OC)nc(C(O)(c2ccc(OC(F)F)cc2)c2ccccc2F)n3CC)n1 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4853889 |  |
IC50 | = | 0.01 | nM | 427.47 | CCn1c(C(O)(c2ccccc2)c2ccccc2)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4846168 |  |
IC50 | = | 0.01 | nM | 500.99 | CCc1c(C(O)(c2ccccc2)c2ccccc2)nn2cc(Cl)c(C(=O)Nc3ncn(CC)n3)cc12 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4870590 |  |
IC50 | = | 0.01 | nM | 463.45 | CCn1c(C(O)(c2ccccc2F)c2ccccc2F)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4550594 |  |
IC50 | = | 0.33 | nM | 500.45 | CC1=NN(c2ccc(OC(F)F)c(-c3cccnc3)c2)C(=O)C1C(=O)Nc1cccc(C(C)(F)F)c1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4449652 |  |
IC50 | = | 0.4626 | nM | 401.41 | CCC(F)(F)c1cccc(NC(=O)C2C(=O)N(c3ccc(OC)cc3)N=C2C)c1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4862805 |  |
IC50 | = | 1.0 | nM | 428.46 | CCn1c(C(O)(c2ccccc2)c2ccccn2)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4859117 |  |
IC50 | = | 1.0 | nM | 433.5 | CCn1c(C(O)(c2ccccc2)c2cccs2)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4867121 |  |
IC50 | = | 1.0 | nM | 509.62 | CCn1cnc(NC(=O)c2cc3c(nc2OC)nc(C(O)(c2cccs2)c2cccs2)n3CC)n1 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4535842 |  |
IC50 | = | 1.0 | nM | 417.41 | COc1ccc(N2N=C(C)C(C(=O)Nc3cccc(C(C)(F)F)c3)C2=O)cc1OC | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4870878 |  |
IC50 | = | 1.0 | nM | 429.44 | CCn1c(C(O)(c2ccccc2)c2ncccn2)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4855352 |  |
IC50 | = | 1.0 | nM | 434.49 | CCn1c(C(O)(c2ccccc2)c2nccs2)nc2nc(OC)c(-c3nnn[nH]3)cc21 | Homo sapiens | CHEMBL4842300 | single protein format |
| CHEMBL4848186 |  |
IC50 | = | 1.0 | nM | 497.56 | CCc1coc(NC(=O)c2cc3c(nc2OC)nc(C(O)(c2ccccc2)c2ccccc2)n3CC)n1 | Homo sapiens | CHEMBL4831472 | single protein format |
| CHEMBL4473187 |  |
IC50 | = | 1.1 | nM | 454.43 | COc1ccc(N2N=C(C)C(C(=O)Nc3cccc(C(C)(F)F)c3)C2=O)cc1-c1ncco1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4463979 |  |
IC50 | = | 2.1 | nM | 417.42 | COC(=O)c1cccc(N2N=C(C)C(C(=O)Nc3cccc(-c4ccco4)c3)C2=O)c1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4560160 |  |
IC50 | = | 2.66 | nM | 423.37 | CC1=NN(c2ccc(OC(F)F)cc2)C(=O)C1C(=O)Nc1cccc(C(C)(F)F)c1 | Homo sapiens | CHEMBL4368259 | cell-based format |
| CHEMBL4548954 |  |
IC50 | = | 3.2 | nM | 389.41 | COc1ccc(N2N=C(C)C(C(=O)Nc3cccc(-c4ccco4)c3)C2=O)cc1 | Homo sapiens | CHEMBL4368259 | cell-based format |