Q9NQU5 | PAK6_HUMAN | Serine/threonine-protein kinase PAK 6 (PAK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 411~658 | |
| PF00786 | PBD - P21-Rho-binding domain | 11~63 |
3D structures mapped by conservation among orthologs
[ Domain: "CRIB domain" // PBD ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL494089 |  |
IC50 | = | 6.0 | nM | 425.49 | CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 | Homo sapiens | CHEMBL1028116 | single protein format |
| CHEMBL3128043 |  |
IC50 | = | 17.1 | nM | 490.64 | Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 | Homo sapiens | CHEMBL3611425 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 31.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328546 | single protein format |
| CHEMBL3128042 |  |
IC50 | = | 36.0 | nM | 406.49 | COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ccnc(N)n1 | Homo sapiens | CHEMBL3129189 | single protein format |
| CHEMBL2334586 |  |
IC50 | = | 60.0 | nM | 332.41 | CC(C)(O)C#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111450 | assay format |
| CHEMBL535 |  |
Ki | = | 500.0 | nM | 398.48 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | Homo sapiens | CHEMBL4035579 | single protein format |