Q9NPH5 | NOX4_HUMAN | NADPH oxidase 4 (NOX4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01794 | Ferric_reduct - Ferric reductase like transmembrane component | 78~204 | |
| PF08022 | FAD_binding_8 - FAD-binding domain | 309~416 | |
| PF08030 | NAD_binding_6 - Ferric reductase NAD binding domain | 423~560 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4859206 |  |
IC50 | = | 10.71 | nM | 306.24 | Oc1ccccc1-c1nc(-c2ccc(C(F)(F)F)cc2)no1 | Homo sapiens | CHEMBL4837837 | single protein format |
| CHEMBL1876217 |  |
IC50 | = | 16.4 | nM | 238.25 | Oc1ccccc1-c1nc(-c2ccccc2)no1 | Homo sapiens | CHEMBL4837837 | single protein format |
| CHEMBL4849098 |  |
IC50 | = | 21.94 | nM | 252.27 | Oc1ccccc1-c1nc(Cc2ccccc2)no1 | Homo sapiens | CHEMBL4837837 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 70.77 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4837837 | single protein format |
| CHEMBL397686 |  |
IC50 | = | 90.0 | nM | 314.55 | [Cl-].c1ccc2c(c1)[I+]c1ccccc1-2 | Homo sapiens | CHEMBL5367008 | cell-based format |
| CHEMBL1242941 |  |
IC50 | = | 170.0 | nM | 410.34 | O=c1c2cc(O)c(O)cc2c2cc(O)c(O)cc2n1Cc1cc([N+](=O)[O-])ccc1O | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL1243033 |  |
IC50 | = | 240.0 | nM | 307.38 | Nc1cccc(Nc2ncnc3c2sc2ccc(N)cc23)c1 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL1242942 |  |
IC50 | = | 260.0 | nM | 394.34 | O=c1c2cc(O)c(O)cc2c2cc(O)c(O)cc2n1Cc1cccc([N+](=O)[O-])c1 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL4208156 |  |
IC50 | = | 500.0 | nM | 400.38 | COc1ccc(S(=O)(=O)N2CCN(c3ccc(C(F)(F)F)cc3)C2=O)cc1 | Homo sapiens | CHEMBL4188460 | single protein format |
| CHEMBL1242968 |  |
IC50 | = | 590.0 | nM | 374.35 | N#Cc1ccccc1Cn1c(=O)c2cc(O)c(O)cc2c2cc(O)c(O)cc21 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL85021 |  |
IC50 | = | 630.0 | nM | 321.42 | CC(C)c1cc(/C=C2\C(=O)Nc3ccccc32)cc(C(C)C)c1O | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL50 |  |
IC50 | = | 680.0 | nM | 302.24 | O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL5218591 |  |
IC50 | = | 680.0 | nM | 389.51 | Cc1ccc(N2CCN(c3nc(N)nc(Nc4ccc(C)c(C)c4)n3)CC2)cc1 | Homo sapiens | CHEMBL5216594 | single protein format |
| CHEMBL5398181 |  |
IC50 | = | 680.0 | nM | 403.53 | Cc1ccc(N2CCN(Cc3nc(N)nc(Nc4ccc(C)c(C)c4)n3)CC2)cc1 | Homo sapiens | CHEMBL5367043 | single protein format |
| CHEMBL470848 |  |
IC50 | = | 740.0 | nM | 316.26 | COc1cc(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c12 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL1243032 |  |
IC50 | = | 790.0 | nM | 286.24 | O=c1c(-c2ccc(O)c(O)c2)c(O)oc2cc(O)ccc12 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL1098724 |  |
IC50 | = | 830.0 | nM | 464.38 | O=c1c(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL151 |  |
IC50 | = | 850.0 | nM | 286.24 | O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12 | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL1243187 |  |
IC50 | = | 910.0 | nM | 358.31 | O=C(N/N=C/c1cccc(O)c1O)C(=O)N/N=C/c1cccc(O)c1O | Homo sapiens | CHEMBL1249158 | cell-based format |
| CHEMBL131407 |  |
IC50 | = | 960.0 | nM | 259.26 | O=C(O)c1cc(NCc2ccccc2O)ccc1O | Homo sapiens | CHEMBL1249158 | cell-based format |