Q9NP56 | PDE7B_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 172~393 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3924897 |  |
IC50 | = | 4.8 | nM | 353.45 | COc1cc(N)ccc1-c1cc2c(c(=O)[nH]1)C(C1CCCCC1)N=[N+]2C | Homo sapiens | CHEMBL3707551 | single protein format |
| CHEMBL2019112 |  |
IC50 | = | 8.0 | nM | 467.6 | COc1cc(N2CCN(C(C)=O)CC2)ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2019816 | single protein format |
| CHEMBL3670399 |  |
IC50 | = | 9.27 | nM | 353.43 | COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL3707551 | single protein format |
| CHEMBL2171422 |  |
IC50 | = | 11.0 | nM | 436.56 | COc1cc(N2CCC(N)CC2)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 | Homo sapiens | CHEMBL2174777 | single protein format |
| CHEMBL2019104 |  |
IC50 | = | 17.0 | nM | 439.59 | COc1cc(N2CCCNCC2)ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2019816 | single protein format |
| CHEMBL2171423 |  |
IC50 | = | 19.0 | nM | 436.56 | COc1cc(N2CCCNCC2)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 | Homo sapiens | CHEMBL2174777 | single protein format |
| CHEMBL2019021 |  |
IC50 | = | 31.0 | nM | 356.45 | COc1cc(N)ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1 | Homo sapiens | CHEMBL2019816 | single protein format |
| CHEMBL4128481 |  |
IC50 | = | 41.3 | nM | 327.39 | COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC | Homo sapiens | CHEMBL4122472 | single protein format |
| CHEMBL2171421 |  |
IC50 | = | 43.0 | nM | 353.43 | COc1cc(N)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 | Homo sapiens | CHEMBL2174777 | single protein format |
| CHEMBL3639692 |  |
IC50 | = | 106.0 | nM | 308.81 | CCCOc1ccc(Cl)c2c1C1(CCCCC1)NC(=O)N2 | Homo sapiens | CHEMBL3707551 | single protein format |
| CHEMBL363097 |  |
IC50 | = | 144.0 | nM | 330.46 | CC(=O)Nc1ccc(-c2nn(C)/c(=N/C3CCCCC3)s2)cc1 | Homo sapiens | CHEMBL3707551 | single protein format |
| CHEMBL3359633 |  |
IC50 | = | 600.0 | nM | 266.71 | O=[N+]([O-])c1ccc(Sc2ccncc2)c(Cl)c1 | Homo sapiens | CHEMBL3383866 | single protein format |
| CHEMBL3741207 |  |
IC50 | < | 1000.0 | nM | 399.43 | COc1cc(-c2ccncc2)cc2c1nc(C)c1c(C)nc(-c3ccc(F)nc3)n12 | Homo sapiens | CHEMBL3742952 | single protein format |
| CHEMBL3769817 |  |
Ki | = | 300.0 | nM | 489.58 | CN1C(=O)c2c(nn(Cc3ccc(-c4ccccn4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12 | Homo sapiens | CHEMBL3772480 | single protein format |
| CHEMBL3770470 |  |
Ki | = | 910.0 | nM | 488.6 | CN1C(=O)c2c(nn(Cc3ccc(-c4ccccc4)cc3)c2Nc2ccccc2)N2C1=N[C@@H]1CCC[C@@H]12 | Homo sapiens | CHEMBL3772480 | single protein format |