Q9HCR9 | PDE11_HUMAN | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 663~897 | |
| PF01590 | GAF - GAF domain | 217~370 | |
| PF01590 | GAF - GAF domain | 402~556 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5437525 |  |
IC50 | = | 0.7 | nM | 466.46 | O=c1cc(Nc2ccccc2)n(-c2ccccc2)c2nc(N3CCOCC3)cc(C(F)(F)F)c12 | Homo sapiens | CHEMBL5391687 | single protein format |
| CHEMBL282515 |  |
IC50 | = | 1.4 | nM | 552.64 | Cn1ccnc1CCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL284070 |  |
IC50 | = | 2.01 | nM | 549.63 | O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1[C@@H]1CCN(CCc2ccccn2)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL33518 |  |
IC50 | = | 2.4 | nM | 549.63 | O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1[C@@H]1CCN(CCc2cccnc2)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL4217054 |  |
IC50 | = | 2.7 | nM | 451.56 | CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)s1 | Homo sapiens | CHEMBL4198223 | cell-based format |
| CHEMBL418594 |  |
IC50 | = | 3.5 | nM | 538.61 | O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1[C@@H]1CCN(CCc2ncc[nH]2)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL4292389 |  |
IC50 | = | 4.0 | nM | 349.39 | CCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc(C)o3)N2C1=O | Homo sapiens | CHEMBL4268482 | cell-based format |
| CHEMBL33121 |  |
IC50 | = | 4.2 | nM | 550.62 | O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1[C@@H]1CCN(CCc2cnccn2)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL285737 |  |
IC50 | = | 4.3 | nM | 543.62 | CCNC(=O)CCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL286309 |  |
IC50 | = | 4.7 | nM | 555.64 | O=C(CCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1)N1CCC1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL33627 |  |
IC50 | = | 4.7 | nM | 543.62 | CN(C)C(=O)CCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL4217579 |  |
IC50 | = | 5.1 | nM | 435.49 | CCc1ccc([C@@H]2c3[nH]c4ccccc4c(=O)c3CN2c2ncc(-c3ccccn3)cn2)o1 | Homo sapiens | CHEMBL4198223 | cell-based format |
| CHEMBL32255 |  |
IC50 | = | 5.5 | nM | 534.62 | O=C1[C@H]2Cc3c([nH]c4ccccc34)[C@@H](c3ccc4c(c3)OCO4)N2C(=O)CN1[C@@H]1CCN(Cc2ccccc2)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL34744 |  |
IC50 | = | 6.5 | nM | 504.63 | Cc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N([C@@H]4CCN(Cc5ccccc5)C4)CC(=O)N23)cc1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL34276 |  |
IC50 | = | 6.7 | nM | 520.63 | COc1ccc([C@@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N([C@@H]4CCN(Cc5ccccc5)C4)CC(=O)N23)cc1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL284560 |  |
IC50 | = | 11.8 | nM | 520.63 | COc1cccc([C@@H]2c3[nH]c4ccccc4c3C[C@@H]3C(=O)N([C@@H]4CCN(Cc5ccccc5)C4)CC(=O)N23)c1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL5432407 |  |
IC50 | = | 12.0 | nM | 424.46 | CCN(CC)C(=O)c1cc(-c2ccnn2C)nc2c1c(C(F)F)nn2-c1ccccc1 | Homo sapiens | CHEMBL5391695 | cell-based format |
| CHEMBL5408783 |  |
IC50 | = | 16.0 | nM | 434.52 | [2H]C([2H])([2H])C([2H])([2H])N(C(=O)c1cc(-c2ccnn2C)nc2c1c(C(F)F)nn2-c1ccccc1)C([2H])([2H])C([2H])([2H])[2H] | Homo sapiens | CHEMBL5391695 | cell-based format |
| CHEMBL34802 |  |
IC50 | = | 22.0 | nM | 516.6 | COCCCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1 | Homo sapiens | CHEMBL759930 | cell-based format |
| CHEMBL33381 |  |
IC50 | = | 31.0 | nM | 514.63 | CCCCCN1CC[C@@H](N2CC(=O)N3[C@H](c4ccc5c(c4)OCO5)c4[nH]c5ccccc5c4C[C@@H]3C2=O)C1 | Homo sapiens | CHEMBL759930 | cell-based format |