Q9HCG7 | GBA2_HUMAN | Non-lysosomal glucosylceramidase (GBA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF04685 | DUF608 - Glycosyl-hydrolase family 116, catalytic region | 521~886 | |
| PF12215 | Glyco_hydr_116N - beta-glucosidase 2, glycosyl-hydrolase family 116 N-term | 151~455 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3354624 |  |
IC50 | = | 0.08 | nM | 433.52 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)cc1F | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354625 |  |
IC50 | = | 0.08 | nM | 433.52 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(F)c1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354627 |  |
IC50 | = | 0.08 | nM | 483.53 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354635 |  |
IC50 | = | 0.1 | nM | 483.53 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(C(F)(F)F)c1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354634 |  |
IC50 | = | 0.1 | nM | 483.53 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)cc1C(F)(F)F | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354626 |  |
IC50 | = | 0.12 | nM | 483.53 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)cc1C(F)(F)F | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354636 |  |
IC50 | = | 0.4 | nM | 433.52 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)cc1F | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354041 |  |
IC50 | = | 0.5 | nM | 429.56 | Cc1ccccc1-c1ccc(COCCCCCN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354637 |  |
IC50 | = | 0.6 | nM | 433.52 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccccc2)c(F)c1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354629 |  |
IC50 | = | 1.0 | nM | 429.56 | C[C@@H](OCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@@H]1CO)c1ccc(-c2ccccc2)cc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354022 |  |
IC50 | = | 1.0 | nM | 389.49 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccccc2c1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354037 |  |
IC50 | = | 1.0 | nM | 463.57 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccc3cccc4ccc1c2c34 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL4459011 |  |
IC50 | = | 1.0 | nM | 333.47 | CCCCCCOCCCCCN1CC(O)C(O)C(O)C1CO | Homo sapiens | CHEMBL4395493 | cell-based format |
| CHEMBL3354048 |  |
IC50 | = | 1.0 | nM | 433.52 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2ccc(F)cc2)cc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354049 |  |
IC50 | = | 1.0 | nM | 433.52 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc(-c2cccc(F)c2)cc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354621 |  |
IC50 | = | 1.0 | nM | 451.51 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCC(F)(F)COCc1ccc(-c2ccccc2)cc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354021 |  |
IC50 | = | 1.0 | nM | 339.43 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccccc1 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL3354019 |  |
IC50 | = | 1.0 | nM | 397.56 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC1C2CC3CC(C2)CC1C3 | Homo sapiens | CHEMBL3384691 | single protein format |
| CHEMBL574645 |  |
IC50 | = | 1.0 | nM | 397.56 | OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 | Homo sapiens | CHEMBL1040323 | single protein format |
| CHEMBL3354035 |  |
IC50 | = | 1.0 | nM | 389.49 | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCc1ccc2ccccc2c1 | Homo sapiens | CHEMBL3384691 | single protein format |