Q9HCE7 | SMUF1_HUMAN | E3 ubiquitin-protein ligase SMURF1 (SMURF1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 - C2 domain | 14~103 | |
| PF00397 | WW - WW domain | 236~265 | |
| PF00397 | WW - WW domain | 308~337 | |
| PF00632 | HECT - HECT-domain (ubiquitin-transferase) | 450~756 |
3D structures mapped by conservation among orthologs
[ Domain: "WW domain" // WW ]
[ Domain: "C2 domain" // C2_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3903549 |  |
IC50 | = | 0.9 | nM | 426.56 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)(C)CC1 | Homo sapiens | CHEMBL3855890 | cell-based format |
| CHEMBL3949800 |  |
IC50 | = | 1.4 | nM | 416.52 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC(C)CO1 | Homo sapiens | CHEMBL3855890 | cell-based format |
| CHEMBL3948610 |  |
IC50 | = | 1.4 | nM | 416.52 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1[C@@H]1CC[C@@H](C)CO1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL3918128 |  |
IC50 | = | 1.8 | nM | 426.56 | CCC1CC=C(c2onc(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)c2C)CC1 | Homo sapiens | CHEMBL3855890 | cell-based format |
| CHEMBL3908757 |  |
IC50 | = | 2.1 | nM | 440.59 | CCC1CC(C)CC=C1c1onc(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL4584197 |  |
IC50 | = | 2.2 | nM | 504.51 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C | Homo sapiens | CHEMBL4418373 | single protein format |
| CHEMBL3979914 |  |
IC50 | = | 2.5 | nM | 452.6 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC2(CCCC2)CC1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL4559578 |  |
IC50 | = | 2.6 | nM | 522.55 | Cc1c(NC(=O)c2noc3c2CCSc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C | Homo sapiens | CHEMBL4418373 | single protein format |
| CHEMBL3945602 |  |
IC50 | = | 2.8 | nM | 440.59 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C(C)C)CC1 | Homo sapiens | CHEMBL3855890 | cell-based format |
| CHEMBL3959606 |  |
IC50 | = | 3.2 | nM | 454.62 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C(C)(C)C)CC1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL4475920 |  |
IC50 | = | 4.5 | nM | 567.35 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2c(Cl)cccc2Cl)n1C | Homo sapiens | CHEMBL4418373 | single protein format |
| CHEMBL3922163 |  |
IC50 | = | 5.7 | nM | 428.58 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1CCC(C)(C)CC1 | Homo sapiens | CHEMBL3855890 | cell-based format |
| CHEMBL4441459 |  |
IC50 | = | 5.9 | nM | 450.54 | COc1ccc2c(c1)CCCc1c(C(=O)Nc3c(C)n(C)n(C4CCCCC4)c3=O)noc1-2 | Homo sapiens | CHEMBL4418373 | single protein format |
| CHEMBL3948012 |  |
IC50 | = | 6.0 | nM | 412.53 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)(C)C1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL3923152 |  |
IC50 | = | 6.0 | nM | 412.53 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCC(C)CC1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL3963970 |  |
IC50 | = | 8.0 | nM | 412.53 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCCCCC1 | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL5413507 |  |
IC50 | = | 11.0 | nM | 480.93 | Cc1c(C(=O)Nc2c(C)n(C)n(-c3ccccc3F)c2=O)noc1-c1ccc(C2CC2)cc1Cl | Homo sapiens | CHEMBL5344287 | single protein format |
| CHEMBL3936702 |  |
IC50 | = | 14.0 | nM | 426.56 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1C1=CCCCC1(C)C | Homo sapiens | CHEMBL4418372 | single protein format |
| CHEMBL4473531 |  |
IC50 | = | 17.0 | nM | 516.45 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2ccccc2F)n1C | Homo sapiens | CHEMBL4418373 | single protein format |
| CHEMBL3896562 |  |
IC50 | = | 19.0 | nM | 402.54 | Cc1c(C(=O)Nc2c(C)n(C)n(C3CCCCC3)c2=O)noc1CCC(C)(C)C | Homo sapiens | CHEMBL4418372 | single protein format |