Q9HC97 | GPR35_HUMAN | G-protein coupled receptor 35 (GPR35)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 38~276 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4100677 |  |
IC50 | = | 8.6 | nM | 354.08 | O=c1oc2c([N+](=O)[O-])c(O)c(Br)cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4079816 |  |
IC50 | = | 13.0 | nM | 320.18 | O=c1oc2c([N+](=O)[O-])c(O)c([N+](=O)[O-])cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4092954 |  |
IC50 | = | 23.0 | nM | 387.98 | O=c1oc2c(Br)c(O)c(Br)cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4082281 |  |
IC50 | = | 31.0 | nM | 330.05 | O=C(O)c1cc2cc(Br)c(O)c([N+](=O)[O-])c2oc1=O | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4081238 |  |
IC50 | = | 56.0 | nM | 363.94 | O=C(O)c1cc2cc(Br)c(O)c(Br)c2oc1=O | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL6246 |  |
IC50 | = | 100.0 | nM | 302.19 | O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23 | Homo sapiens | CHEMBL2039375 | cell-based format |
| CHEMBL559337 |  |
IC50 | = | 110.0 | nM | 248.19 | O=C(O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 | Homo sapiens | CHEMBL2039375 | cell-based format |
| CHEMBL1914588 |  |
IC50 | = | 110.0 | nM | 277.16 | Cc1c(C(=O)O)sc2c(Br)csc12 | Homo sapiens | CHEMBL2039375 | cell-based format |
| CHEMBL4085211 |  |
IC50 | = | 330.0 | nM | 338.08 | O=c1oc2c([N+](=O)[O-])cc(Br)cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4065291 |  |
IC50 | = | 380.0 | nM | 371.98 | O=c1oc2c(Br)cc(Br)cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL2037378 |  |
IC50 | = | 390.0 | nM | 537.43 | CC(=O)NCCc1ccc(O)c(-c2c(O)c(O)c3c(c2O)C(=O)c2c(cc(O)c(C(=O)O)c2C(=O)O)C3=O)c1 | Homo sapiens | CHEMBL2039375 | cell-based format |
| CHEMBL4103143 |  |
IC50 | = | 460.0 | nM | 402.0 | COc1c(Br)cc2cc(-c3nnn[nH]3)c(=O)oc2c1Br | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4073902 |  |
IC50 | = | 483.0 | nM | 309.08 | O=c1oc2cc(O)c(Br)cc2cc1-c1nnn[nH]1 | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL1384502 |  |
IC50 | = | 522.0 | nM | 482.58 | CC(/C=C1\SC(=S)N(CCCC(=O)Nc2ccc(C(=O)O)c(O)c2)C1=O)=C\c1ccccc1 | Homo sapiens | CHEMBL2429570 | cell-based format |
| CHEMBL1708510 |  |
IC50 | = | 574.0 | nM | 395.44 | COC(=O)c1cnn(-c2ccc(F)cc2F)c1/C=N/NC(=S)NC(C)(C)C | Homo sapiens | CHEMBL2429570 | cell-based format |
| CHEMBL4093683 |  |
IC50 | = | 590.0 | nM | 358.97 | COc1c(Br)cc2cc(C#N)c(=O)oc2c1Br | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4066109 |  |
IC50 | = | 650.0 | nM | 295.05 | N#Cc1cc2cc(Br)cc([N+](=O)[O-])c2oc1=O | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL4105535 |  |
IC50 | = | 750.0 | nM | 377.97 | COc1c(Br)cc2cc(C(=O)O)c(=O)oc2c1Br | Homo sapiens | CHEMBL4042614 | cell-based format |
| CHEMBL2425821 |  |
Ki | = | 0.589 | nM | 454.18 | COc1cc(F)c(C(=O)Nc2cc(Br)cc3c(=O)cc(C(=O)O)oc23)c(F)c1 | Homo sapiens | CHEMBL2429574 | cell-based format |
| CHEMBL2392171 |  |
Ki | = | 0.938 | nM | 457.06 | O=C(O)c1cc(=O)c2cc(Br)cc(NC(=O)c3ccc(Cl)cc3Cl)c2o1 | Homo sapiens | CHEMBL2429574 | cell-based format |