Q9HC29 | NOD2_HUMAN | Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00619 | CARD - Caspase recruitment domain | 32~117 | |
| PF05729 | NACHT - NACHT domain | 293~462 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 898~920 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 927~948 | |
| PF13516 | LRR_6 - Leucine Rich repeat | 981~1003 | |
| PF17776 | NLRC4_HD2 - NLRC4 helical domain HD2 | 603~756 | |
| PF17779 | NOD2_WH - NOD2 winged helix domain | 546~588 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4781373 |  |
IC50 | = | 1.0 | nM | 511.65 | CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(OC)c1OC | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4847211 |  |
IC50 | = | 3.0 | nM | 554.52 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4853179 |  |
IC50 | = | 4.0 | nM | 478.0 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4514780 |  |
IC50 | = | 4.0 | nM | 458.57 | CC(C)(C)S(=O)(=O)c1cc2c(Nc3ccc4scnc4c3)ncnc2cc1OCCO | Homo sapiens | CHEMBL4367438 | cell-based format |
| CHEMBL4870434 |  |
IC50 | = | 5.0 | nM | 459.55 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(O)cc4)c(=O)n(C)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4858463 |  |
IC50 | = | 9.0 | nM | 588.54 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4859716 |  |
IC50 | = | 13.0 | nM | 556.49 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL136244 |  |
IC50 | = | 14.0 | nM | 443.55 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL136106 |  |
IC50 | = | 15.0 | nM | 457.58 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4799077 |  |
IC50 | = | 16.0 | nM | 499.61 | CCCS(=O)(=O)Nc1cc(-c2cc(-c3cccc(N4CCNCC4)c3)cnc2N)cc(F)c1OC | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4861488 |  |
IC50 | = | 20.0 | nM | 440.91 | Cn1c(=O)c(-c2ccccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4864600 |  |
IC50 | = | 22.0 | nM | 475.36 | Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2cnc(Nc3cccc(S(C)(=O)=O)c3)nc21 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4789724 |  |
IC50 | = | 26.0 | nM | 499.61 | CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(F)c1OC | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL1713298 |  |
IC50 | = | 30.0 | nM | 426.44 | O=C(Nc1ccc(OC(F)(F)F)cc1)c1ccc(CN2CCc3ccccc3C2)cc1 | Homo sapiens | CHEMBL2020291 | cell-based format |
| CHEMBL49120 |  |
IC50 | = | 37.0 | nM | 512.44 | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 | Homo sapiens | CHEMBL4815730 | cell-based format |
| CHEMBL4795976 |  |
IC50 | = | 46.0 | nM | 495.65 | CCOc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4793153 |  |
IC50 | = | 46.0 | nM | 516.07 | CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(Cl)c1OC | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4776631 |  |
IC50 | = | 53.0 | nM | 515.64 | COc1cc(NS(=O)(=O)c2ccccc2)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4781705 |  |
IC50 | = | 121.0 | nM | 481.62 | COc1cc(NS(=O)(=O)C(C)C)cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)c1 | Homo sapiens | CHEMBL4771085 | cell-based format |
| CHEMBL4788375 |  |
IC50 | = | 129.0 | nM | 495.65 | CCCS(=O)(=O)Nc1cc(-c2cc(-c3ccc(N4CCNCC4)cc3)cnc2N)cc(C)c1OC | Homo sapiens | CHEMBL4771085 | cell-based format |