Q9HBH1 | DEFM_HUMAN | Peptide deformylase, mitochondrial (PDF)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01327 | Pep_deformylase - Polypeptide deformylase | 66~231 |
3D structures mapped by conservation among orthologs
[ Domain: "Peptide deformylase" // Pep_deformylase ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL122067 |  |
IC50 | = | 1.0 | nM | 329.44 | CCCC[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C | Homo sapiens | CHEMBL762381 | single protein format |
| CHEMBL4637933 |  |
IC50 | = | 2.78 | nM | 434.56 | Cc1cnc(NC(=O)[C@@H]2CC3(CC3)CN2C(=O)[C@@H](CC(=O)NO)CC2CCCC2)s1 | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4638057 |  |
IC50 | = | 2.99 | nM | 434.56 | Cc1csc(NC(=O)[C@@H]2CC3(CC3)CN2C(=O)[C@@H](CC(=O)NO)CC2CCCC2)n1 | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4632607 |  |
IC50 | = | 3.58 | nM | 427.55 | Cc1ccc(NC(=O)[C@@H]2CC3(CC3)CN2C(=O)[C@@H](CC(=O)NO)CC2CCCC2)cc1 | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4641062 |  |
IC50 | = | 3.77 | nM | 438.53 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccccc2)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4635911 |  |
IC50 | = | 4.11 | nM | 524.52 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(F)cc2C(F)(F)F)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4643984 |  |
IC50 | = | 4.24 | nM | 494.64 | CCCCc1ccc(-c2noc([C@@H]3CC4(CC4)CN3C(=O)[C@@H](CC(=O)NO)CC3CCCC3)n2)cc1 | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4649534 |  |
IC50 | = | 4.85 | nM | 524.52 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(C(F)(F)F)cc2F)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4639327 |  |
IC50 | = | 4.92 | nM | 406.46 | CCCC[C@H](CC(=O)NO)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1ccc(F)cn1 | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4641416 |  |
IC50 | = | 5.01 | nM | 457.51 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(F)cn2)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4636545 |  |
IC50 | = | 5.01 | nM | 478.59 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(C3CC3)cc2)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4643967 |  |
IC50 | = | 5.48 | nM | 517.42 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(Br)cc2)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4636221 |  |
IC50 | = | 5.87 | nM | 432.5 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1ccc(F)cn1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4634572 |  |
IC50 | = | 5.87 | nM | 415.49 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1cnccn1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL90193 |  |
IC50 | = | 6.0 | nM | 369.51 | CN(C)C(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)CN(O)C=O)C(C)(C)C | Homo sapiens | CHEMBL762382 | single protein format |
| CHEMBL4637166 |  |
IC50 | = | 6.12 | nM | 492.41 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1ccc(Br)cc1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4640974 |  |
IC50 | = | 6.42 | nM | 413.52 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1ccccc1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL4645966 |  |
IC50 | = | 6.47 | nM | 540.97 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1c1nc(-c2ccc(C(F)(F)F)cc2Cl)no1)NO | Homo sapiens | CHEMBL4619395 | assay format |
| CHEMBL431210 |  |
IC50 | = | 7.0 | nM | 329.44 | CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C | Homo sapiens | CHEMBL762382 | single protein format |
| CHEMBL4635093 |  |
IC50 | = | 7.01 | nM | 499.51 | O=C(C[C@@H](CC1CCCC1)C(=O)N1CC2(CC2)C[C@H]1C(=O)Nc1ccc(F)cc1C(F)(F)F)NO | Homo sapiens | CHEMBL4619395 | assay format |