Q9HAZ1 | CLK4_HUMAN | Dual specificity protein kinase CLK4 (CLK4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 159~475 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4797564 |  |
IC50 | = | 0.61 | nM | 382.43 | CNc1nc(NCc2ncccn2)c2c(-c3ccc4ncccc4c3)c[nH]c2n1 | Homo sapiens | CHEMBL5237394 | single protein format |
| CHEMBL5405233 |  |
IC50 | = | 1.0 | nM | 344.46 | O=C1NC(NC2CCCSC2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5428651 |  |
IC50 | = | 1.0 | nM | 394.5 | O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL4784318 |  |
IC50 | = | 1.0 | nM | 427.51 | CN1CCN(c2cc(C(=O)Nc3cc4cc(-c5cnn(C)c5)ccc4cn3)ccn2)CC1 | Homo sapiens | CHEMBL5105982 | single protein format |
| CHEMBL5404544 |  |
IC50 | = | 1.0 | nM | 364.43 | O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL4531334 |  |
IC50 | = | 1.98 | nM | 482.59 | CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5ccncc5)ccc4n3)cc2)CC1 | Homo sapiens | CHEMBL4883204 | single protein format |
| CHEMBL5404416 |  |
IC50 | = | 2.0 | nM | 361.45 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2[nH]cnc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5412565 |  |
IC50 | = | 2.0 | nM | 421.57 | CN(C)C12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 2.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5417147 |  |
IC50 | = | 2.0 | nM | 408.53 | COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5422654 |  |
IC50 | = | 2.0 | nM | 435.55 | CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5409574 |  |
IC50 | = | 2.0 | nM | 471.61 | CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5414514 |  |
IC50 | = | 2.0 | nM | 356.45 | O=C1NC(N[C@@H]2CCCCC[C@@H]2O)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5418722 |  |
IC50 | = | 2.0 | nM | 461.59 | O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5429691 |  |
IC50 | = | 2.1 | nM | 355.44 | COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3[nH]cnc3c2)C(=O)N1C | Homo sapiens | CHEMBL5378445 | single protein format |
| CHEMBL4082113 |  |
IC50 | = | 2.3 | nM | 329.4 | COc1ccc2sc(C(=O)N(C)Cc3cccc(F)c3)cc2c1 | Homo sapiens | CHEMBL5237399 | single protein format |
| CHEMBL5438293 |  |
IC50 | = | 3.0 | nM | 362.43 | O=C1NC(NC23CC4CC(CC(C4)C2)C3)=N/C1=C\c1ccc2ncoc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5420645 |  |
IC50 | = | 3.0 | nM | 375.48 | Cn1cnc2ccc(/C=C3\N=C(NC45CC6CC(CC(C6)C4)C5)NC3=O)cc21 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5426735 |  |
IC50 | = | 3.0 | nM | 346.43 | CC(C)C[C@H](CF)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5363957 | single protein format |
| CHEMBL5396550 |  |
IC50 | = | 3.0 | nM | 376.43 | O=C1NC(NC2CCCCC(F)(F)C2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363957 | single protein format |