Q9HAU4 | SMUF2_HUMAN | E3 ubiquitin-protein ligase SMURF2 (SMURF2)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00168 | C2 | 13–102 | |
| PF00397 | WW | 159–188 | |
| PF00397 | WW | 253–282 | |
| PF00397 | WW | 299–328 | |
| PF00632 | HECT | 444–747 |
3D structures mapped by conservation among orthologs
[ Domain: "WW domain" // WW ]
[ Domain: "C2 domain" // C2_1 ]
[ Domain: "Hect, E3 ligase catalytic domain" // HECT ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4584197 |  |
IC50 | = | 175.0 | nM | 504.51 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C | Homo sapiens | CHEMBL4418374 | single protein format |
| CHEMBL4475920 |  |
IC50 | = | 390.0 | nM | 567.35 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2c(Cl)cccc2Cl)n1C | Homo sapiens | CHEMBL4418374 | single protein format |
| CHEMBL4559578 |  |
IC50 | = | 725.0 | nM | 522.55 | Cc1c(NC(=O)c2noc3c2CCSc2cc(OC(F)(F)F)ccc2-3)c(=O)n(C2CCCCC2)n1C | Homo sapiens | CHEMBL4418374 | single protein format |
| CHEMBL4468431 |  |
IC50 | = | 740.0 | nM | 505.02 | Cc1c(NC(=O)c2noc3c2CCCc2cc(CC(C)C)ccc2-3)c(=O)n(-c2ccccc2Cl)n1C | Homo sapiens | CHEMBL4418374 | single protein format |
| CHEMBL4473531 |  |
IC50 | = | 830.0 | nM | 516.45 | Cc1c(NC(=O)c2noc3c2CCCc2cc(OC(F)(F)F)ccc2-3)c(=O)n(-c2ccccc2F)n1C | Homo sapiens | CHEMBL4418374 | single protein format |