Q9H9B1 | EHMT1_HUMAN | Histone-lysine N-methyltransferase EHMT1 (EHMT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00856 | SET - SET domain | 1137~1243 | |
| PF05033 | Pre-SET - Pre-SET motif | 1016~1118 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 834~903 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 910~985 | |
| PF13637 | Ank_4 - Ankyrin repeats (many copies) | 777~826 | |
| PF21533 | EHMT1-2_CRR - Histone-lysine N-methyltransferase EHMT1/EHMT2, Cys-rich region | 540~633 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "Ankyrin repeat" // Ank_2 ]
[ Domain: "Zn3Cys9 preSET domain-related" // Pre-SET ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5191361 |  |
IC50 | = | 1.3 | nM | 591.76 | COc1cc2nc(N3CCN(CCCCCC(=O)NO)CC3)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC | Homo sapiens | CHEMBL5144717 | single protein format |
| CHEMBL5171820 |  |
IC50 | = | 1.6 | nM | 543.71 | COc1cc2nc(N3CCN(CCCCCC(=O)NO)CC3)nc(NC3CCN(C(C)C)CC3)c2cc1OC | Homo sapiens | CHEMBL5144717 | single protein format |
| CHEMBL578227 |  |
IC50 | = | 4.0 | nM | 414.55 | COc1cc2nc(N3CCCN(C)CC3)nc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL4005607 | assay format |
| CHEMBL4094717 |  |
IC50 | = | 4.0 | nM | 399.54 | COc1cc2nc(N(C)C3CCCC3)nc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL4072211 |  |
IC50 | = | 5.0 | nM | 373.5 | CCCN(C)c1nc(NC2CCN(C)CC2)c2cc(OC)c(OC)cc2n1 | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL5410724 |  |
IC50 | = | 5.0 | nM | 482.63 | C=CC(=O)N(C)c1nc(NC2CCN(C)CC2)c2cc(OC)c(OCCCN3CCCC3)cc2n1 | Homo sapiens | CHEMBL5343792 | single protein format |
| CHEMBL4100004 |  |
IC50 | = | 6.0 | nM | 413.57 | COc1cc2nc(N(C)C3CCCCC3)nc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL4582775 |  |
IC50 | = | 6.0 | nM | 491.68 | COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1C#CCN1CCCC1 | Homo sapiens | CHEMBL4350283 | cell-based format |
| CHEMBL4066769 |  |
IC50 | = | 6.0 | nM | 386.5 | COc1cc2nc(N3CCOCC3)cc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL4086403 |  |
IC50 | = | 7.0 | nM | 401.56 | CCCCCCNc1nc(NC2CCN(C)CC2)c2cc(OC)c(OC)cc2n1 | Homo sapiens | CHEMBL4005607 | assay format |
| CHEMBL4461224 |  |
IC50 | = | 9.0 | nM | 469.68 | COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1CCCN(C)C | Homo sapiens | CHEMBL4350283 | cell-based format |
| CHEMBL4467219 |  |
IC50 | = | 9.0 | nM | 495.72 | COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1CCCN1CCCC1 | Homo sapiens | CHEMBL4350283 | cell-based format |
| CHEMBL5201140 |  |
IC50 | = | 9.2 | nM | 522.65 | COc1cc2nc(NCCCCCC(=O)NO)nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC | Homo sapiens | CHEMBL5144717 | single protein format |
| CHEMBL4568910 |  |
IC50 | = | 11.0 | nM | 465.65 | COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1C#CCN(C)C | Homo sapiens | CHEMBL4350283 | cell-based format |
| CHEMBL4085546 |  |
IC50 | = | 11.0 | nM | 415.54 | CCCN1CCC(Nc2nc(N3CCOCC3)nc3cc(OC)c(OC)cc23)CC1 | Homo sapiens | CHEMBL4005607 | assay format |
| CHEMBL576260 |  |
IC50 | = | 11.0 | nM | 345.45 | COc1cc2nc(N(C)C)nc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL4088064 |  |
IC50 | = | 11.0 | nM | 400.57 | CCCCCCNc1cc(NC2CCN(C)CC2)c2cc(OC)c(OC)cc2n1 | Homo sapiens | CHEMBL4056671 | assay format |
| CHEMBL5204152 |  |
IC50 | = | 11.0 | nM | 488.63 | COc1cc2nc(NCCCCCCC(=O)NO)nc(NC3CCN(C(C)C)CC3)c2cc1OC | Homo sapiens | CHEMBL5144717 | single protein format |
| CHEMBL5182385 |  |
IC50 | = | 11.0 | nM | 446.55 | COc1cc2nc(NCCCCCC(=O)NO)nc(NC3CCN(C)CC3)c2cc1OC | Homo sapiens | CHEMBL5144717 | single protein format |
| CHEMBL4532743 |  |
IC50 | = | 12.0 | nM | 505.67 | COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1C#CCN1CCCC1=O | Homo sapiens | CHEMBL4350283 | cell-based format |