Q9H8M2 | BRD9_HUMAN | Bromodomain-containing protein 9 (BRD9)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00439 | Bromodomain - Bromodomain | 146~228 | |
| PF12024 | DUF3512 - Domain of unknown function (DUF3512) | 287~464 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain" // Bromodomain ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5268484 |  |
IC50 | = | 5.0 | nM | 451.52 | C/C=C/Cn1cc(-c2cc(OC)c(C(=O)N3CCOCC3)cc2OC)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL5279182 |  |
IC50 | = | 6.0 | nM | 421.5 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(OC)c2)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL5285110 |  |
IC50 | = | 7.0 | nM | 425.92 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL5289762 |  |
IC50 | = | 8.0 | nM | 396.49 | C/C=C/Cn1cc(-c2cc(OC)c(C(C)(C)O)cc2OC)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL5268936 |  |
IC50 | = | 8.0 | nM | 416.48 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C#N)c2)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL3823177 |  |
IC50 | = | 9.0 | nM | 343.43 | COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN1CC(N)C1 | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL5280605 |  |
IC50 | = | 9.0 | nM | 405.5 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C)c2)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL3769507 |  |
IC50 | = | 10.4 | nM | 497.56 | CCn1cc(-c2cccc(C(F)(F)F)c2)c2sc(C(=N)NC3CCS(=O)(=O)CC3)cc2c1=O | Homo sapiens | CHEMBL4650195 | single protein format |
| CHEMBL5284261 |  |
IC50 | = | 12.0 | nM | 391.47 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc(C)[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL3823478 |  |
IC50 | = | 19.0 | nM | 353.42 | COc1cc(-c2cn(C)c(=O)c3cnccc23)cc(OC)c1CN(C)C | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL3823369 |  |
IC50 | = | 21.0 | nM | 344.41 | COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN1CC(O)C1 | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL3824146 |  |
IC50 | = | 30.0 | nM | 352.43 | COc1cc(-c2cn(C)c(=O)c3ccccc23)cc(OC)c1CN(C)C | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL5270178 |  |
IC50 | = | 31.0 | nM | 377.44 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCOCC3)cc2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL4557699 |  |
IC50 | = | 35.0 | nM | 411.89 | C/C=C/Cn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)n2cncc2c1=O | Homo sapiens | CHEMBL4481830 | single protein format |
| CHEMBL3823599 |  |
IC50 | = | 37.0 | nM | 330.43 | COc1cc(-c2cn(C)c(=O)c(C)c2C)cc(OC)c1CN(C)C | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL3824312 |  |
IC50 | = | 37.0 | nM | 354.41 | COc1cc(-c2cn(C)c(=O)c3cncnc23)cc(OC)c1CN(C)C | Homo sapiens | CHEMBL3826483 | assay format |
| CHEMBL5282240 |  |
IC50 | = | 48.0 | nM | 352.43 | C/C=C/Cn1cc(-c2ccc(C(C)(C)O)cc2OC)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL4065619 |  |
IC50 | = | 49.2 | nM | 333.39 | CC(=O)c1cc(-c2cc(C(=O)NC3CC3)ccc2C)c2ncccn12 | Homo sapiens | CHEMBL4650195 | single protein format |
| CHEMBL5286608 |  |
IC50 | = | 53.0 | nM | 322.41 | C/C=C/Cn1cc(-c2ccc(C(C)(C)O)cc2)c2cc[nH]c2c1=O | Homo sapiens | CHEMBL5261606 | single protein format |
| CHEMBL3822990 |  |
IC50 | = | 54.0 | nM | 316.4 | COc1cc(-c2cc(C)c(=O)n(C)c2)cc(OC)c1CN(C)C | Homo sapiens | CHEMBL3826483 | assay format |