Q9H7Z7 | PGES2_HUMAN | Prostaglandin E synthase 2 (PTGES2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13417 | GST_N_3 - Glutathione S-transferase, N-terminal domain | 104~172 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL180650 |  |
IC50 | = | 3.0 | nM | 540.08 | Cc1ccccc1-c1ccc(-c2ccc3c(c2)c(C)c(CC(C)(C)C(=O)O)n3Cc2ccc(Cl)cc2)cc1F | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL180617 |  |
IC50 | = | 4.0 | nM | 560.5 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4Cl)c(F)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL369525 |  |
IC50 | = | 5.0 | nM | 556.08 | COc1ccccc1-c1ccc(-c2ccc3c(c2)c(C)c(CC(C)(C)C(=O)O)n3Cc2ccc(Cl)cc2)cc1F | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL368241 |  |
IC50 | = | 6.0 | nM | 568.09 | CC(=O)c1ccccc1-c1ccc(-c2ccc3c(c2)c(C)c(CC(C)(C)C(=O)O)n3Cc2ccc(Cl)cc2)cc1F | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL182032 |  |
IC50 | = | 7.0 | nM | 526.05 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4)c(F)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL362836 |  |
IC50 | = | 8.0 | nM | 544.04 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4F)c(F)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL181728 |  |
IC50 | = | 12.0 | nM | 527.04 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4cccnc4)c(F)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL362242 |  |
IC50 | = | 16.0 | nM | 508.06 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4)cc3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL362675 |  |
IC50 | = | 22.0 | nM | 542.51 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4ccccc4)c(Cl)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL3962955 |  |
IC50 | = | 22.0 | nM | 453.93 | COc1ncc(-c2cccc(S(=O)(=O)Nc3ccccc3S(N)(=O)=O)c2)cc1Cl | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL183596 |  |
IC50 | = | 31.0 | nM | 540.08 | Cc1ccc(-c2ccc(-c3ccc4c(c3)c(C)c(CC(C)(C)C(=O)O)n4Cc3ccc(Cl)cc3)cc2F)cc1 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL3986331 |  |
IC50 | = | 31.0 | nM | 509.53 | NS(=O)(=O)c1ccccc1NS(=O)(=O)CCc1ccc(C#Cc2ccc(C(F)(F)F)cc2)nc1 | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL181792 |  |
IC50 | = | 32.0 | nM | 528.03 | Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(-c3ccc(-c4cnccn4)c(F)c3)cc12 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL183878 |  |
IC50 | = | 33.0 | nM | 540.08 | Cc1cccc(-c2ccc(-c3ccc4c(c3)c(C)c(CC(C)(C)C(=O)O)n4Cc3ccc(Cl)cc3)cc2F)c1 | Homo sapiens | CHEMBL829449 | single protein format |
| CHEMBL3904203 |  |
IC50 | = | 36.0 | nM | 402.88 | COc1cc(Cl)ccc1/C=C/S(=O)(=O)Nc1ccccc1S(N)(=O)=O | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL3897379 |  |
IC50 | = | 40.0 | nM | 472.52 | NS(=O)(=O)c1ccc(F)cc1NS(=O)(=O)/C=C/c1ccc(-c2cc3ccccc3o2)cc1 | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL3961959 |  |
IC50 | = | 41.0 | nM | 462.59 | NS(=O)(=O)c1cc(CO)ccc1NS(=O)(=O)CCc1ccc(C#CC2CCCC2)cc1 | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL3943504 |  |
IC50 | = | 44.0 | nM | 404.47 | NS(=O)(=O)c1ccccc1NS(=O)(=O)/C=C/c1ccc(-c2ccco2)cc1 | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL3943346 |  |
IC50 | = | 55.0 | nM | 418.54 | CC(C)(C)C#Cc1ccc(/C=C/S(=O)(=O)Nc2ccccc2S(N)(=O)=O)cc1 | Homo sapiens | CHEMBL3887295 | assay format |
| CHEMBL3965498 |  |
IC50 | = | 57.0 | nM | 422.46 | NS(=O)(=O)c1c(F)cccc1NS(=O)(=O)/C=C/c1ccc(-c2ccco2)cc1 | Homo sapiens | CHEMBL3887295 | assay format |