Q9H773 | DCTP1_HUMAN | dCTP pyrophosphatase 1 (DCTPP1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF12643 | MazG-like - MazG-like family | 63~144 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1578365 |  |
IC50 | = | 19.0 | nM | 328.35 | COc1ccc(-c2nn3c(-c4ccco4)nnc3s2)cc1OC | Homo sapiens | CHEMBL4008373 | assay format |
| CHEMBL4072033 |  |
IC50 | = | 19.0 | nM | 492.03 | Cc1c(Cl)cccc1S(=O)(=O)N1CCN(c2ccc(C(=O)NCc3cccs3)nn2)CC1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3771346 |  |
IC50 | = | 19.0 | nM | 350.21 | Cc1ccc(Cn2c(C)nc3c([N+](=O)[O-])c(Cl)c(Cl)cc32)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4065181 |  |
IC50 | = | 20.0 | nM | 344.42 | COc1ccc(-c2nn3c(-c4cccs4)nnc3s2)cc1OC | Homo sapiens | CHEMBL4008373 | assay format |
| CHEMBL3771039 |  |
IC50 | = | 21.0 | nM | 352.18 | Cc1nc2c([N+](=O)[O-])c(Cl)c(Cl)cc2n1Cc1ccc(O)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4082508 |  |
IC50 | = | 25.0 | nM | 490.95 | O=C(NCc1ccc(F)cc1)c1ccc(N2CCN(S(=O)(=O)c3cccnc3Cl)CC2)nn1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3769835 |  |
IC50 | = | 27.0 | nM | 406.03 | O=[N+]([O-])c1c(Cl)c(Cl)cc2c1nc(C1CC1)n2Cc1ccc(B(O)O)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4060634 |  |
IC50 | = | 34.0 | nM | 433.92 | C#CCNC(=O)c1ccc(N2CCN(S(=O)(=O)c3cccc(Cl)c3C)CC2)nn1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3769727 |  |
IC50 | = | 34.0 | nM | 394.21 | CC(=O)Oc1ccc(Cn2c(C)nc3c([N+](=O)[O-])c(Cl)c(Cl)cc32)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4075978 |  |
IC50 | = | 36.0 | nM | 470.53 | Cc1ncccc1S(=O)(=O)N1CCN(c2ccc(C(=O)NCc3ccc(F)cc3)nn2)CC1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL4101470 |  |
IC50 | = | 38.0 | nM | 452.54 | Cc1ccccc1S(=O)(=O)N1CCN(c2ccc(C(=O)OCc3ccccc3)nn2)CC1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3771227 |  |
IC50 | = | 41.0 | nM | 366.2 | COc1ccc(Cn2c(C)nc3c([N+](=O)[O-])c(Cl)c(Cl)cc32)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4091797 |  |
IC50 | = | 41.0 | nM | 485.57 | C#CCOC(=O)c1ccc(N2CCN(S(=O)(=O)c3ccccc3N3CCC(O)CC3)CC2)nn1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3771237 |  |
IC50 | = | 46.0 | nM | 380.0 | Cc1nc2c([N+](=O)[O-])c(Cl)c(Cl)cc2n1Cc1ccc(B(O)O)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL3770446 |  |
IC50 | = | 46.0 | nM | 380.0 | Cc1nc2c([N+](=O)[O-])c(Cl)c(Cl)cc2n1Cc1cccc(B(O)O)c1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL3771105 |  |
IC50 | = | 47.0 | nM | 491.1 | Cc1nc2c([N+](=O)[O-])c(Cl)c(Cl)cc2n1Cc1ccc(B2OC(=O)CN(C)CC(=O)O2)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL3769687 |  |
IC50 | = | 49.0 | nM | 336.18 | Cc1nc2c([N+](=O)[O-])c(Cl)c(Cl)cc2n1Cc1ccccc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4098065 |  |
IC50 | = | 51.0 | nM | 457.58 | Cc1ccccc1S(=O)(=O)N1CCN(c2ccc(C(=O)NCc3cccs3)nn2)CC1 | Homo sapiens | CHEMBL4016019 | assay format |
| CHEMBL3771138 |  |
IC50 | = | 57.0 | nM | 325.37 | COc1ccc(Cn2c(C)nc3c([N+](=O)[O-])c(C)c(C)cc32)cc1 | Homo sapiens | CHEMBL3772975 | assay format |
| CHEMBL4061657 |  |
IC50 | = | 65.0 | nM | 469.54 | Cc1ccccc1S(=O)(=O)N1CCN(c2ccc(C(=O)NCc3ccc(F)cc3)nn2)CC1 | Homo sapiens | CHEMBL4016019 | assay format |