Q9H6Z9 | EGLN3_HUMAN | Prolyl hydroxylase EGLN3 (EGLN3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF13640 | 2OG-FeII_Oxy_3 - 2OG-Fe(II) oxygenase superfamily | 121~212 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3115315 |  |
IC50 | = | 0.0 | nM | 300.34 | N#Cc1cnc(-c2nc(CC(=O)N3CCC3)cs2)c(O)c1 | Homo sapiens | CHEMBL3118411 | cell-based format |
| CHEMBL3115282 |  |
IC50 | = | 0.8 | nM | 434.41 | N#Cc1ccccc1Cn1c(=O)c(C(=O)NCC(=O)O)c(O)n(Cc2ccccc2)c1=O | Homo sapiens | CHEMBL3119781 | assay format |
| CHEMBL3115284 |  |
IC50 | = | 0.8 | nM | 469.93 | CC(C)(C)c1ccc(Cn2nc(-c3ccc(Cl)cc3)c(O)c(C(=O)NCC(=O)O)c2=O)cc1 | Homo sapiens | CHEMBL3119781 | assay format |
| CHEMBL3115283 |  |
IC50 | = | 0.8 | nM | 504.37 | CC(C)(C)c1ccc(Cn2c(-c3c(Cl)cccc3Cl)nc(O)c(C(=O)NCC(=O)O)c2=O)cc1 | Homo sapiens | CHEMBL3119781 | assay format |
| CHEMBL2041190 |  |
IC50 | = | 0.8 | nM | 562.63 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3cnccn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL4173371 |  |
IC50 | = | 1.0 | nM | 472.91 | COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)sc3c2=O)nc1OC | Homo sapiens | CHEMBL4149402 | assay format |
| CHEMBL3115292 |  |
IC50 | = | 1.0 | nM | 404.22 | O=C(O)CNC(=O)c1c(O)c(Br)cc2c1ncn2Cc1ccccc1 | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115290 |  |
IC50 | = | 1.0 | nM | 324.3 | O=C(O)CNC(=O)c1c(O)c(-c2cccnc2)cc2nccnc12 | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115295 |  |
IC50 | = | 1.0 | nM | 482.47 | COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc5c(c4)OCO5)sc3c2=O)nc1OC | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115296 |  |
IC50 | = | 1.0 | nM | 467.87 | COc1ccc(-n2c(=O)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)ncc3c2=O)nc1OC | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115294 |  |
IC50 | = | 1.0 | nM | 503.01 | COc1ccc(-n2c(=S)[nH]c3sc(C(=O)NCc4ccc(Cl)cc4)c(C)c3c2=O)nc1OC | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115293 |  |
IC50 | = | 1.0 | nM | 488.98 | COc1ccc(-n2c(=S)[nH]c3cc(C(=O)NCc4ccc(Cl)cc4)sc3c2=O)nc1OC | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115291 |  |
IC50 | = | 1.0 | nM | 439.48 | O=C(O)CNC(=O)c1c2ncn(Cc3ccccc3)c2cc2c1ncn2Cc1ccccc1 | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL3115289 |  |
IC50 | = | 1.0 | nM | 322.32 | O=C(O)CNC(=O)c1c(O)ccc2cc(-c3ccccc3)cnc12 | Homo sapiens | CHEMBL3119779 | assay format |
| CHEMBL2041175 |  |
IC50 | = | 1.6 | nM | 577.67 | Cc1cccnc1CN1CCC2(CC1)C(=O)N(c1ccc(-c3ccc4scnc4c3)cc1)C(=O)N2c1cc(O)ncn1 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL2041193 |  |
IC50 | = | 1.6 | nM | 562.63 | Cc1cc(C(=O)O)ccc1-c1ccc(N2C(=O)N(c3ccncn3)C3(CCN(Cc4ncccc4C)CC3)C2=O)cc1 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL2043169 |  |
IC50 | = | 1.7 | nM | 578.63 | COc1cc(N2C(=O)N(c3ccc(-c4cccc(C(=O)O)c4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL2043325 |  |
IC50 | = | 1.9 | nM | 592.66 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)cc4C)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL2041185 |  |
IC50 | = | 2.0 | nM | 592.66 | COc1nccnc1N1C(=O)N(c2ccc(-c3ccc(C(=O)O)cc3C)cc2)C(=O)C12CCN(Cc1ncccc1C)CC2 | Homo sapiens | CHEMBL2045988 | single protein format |
| CHEMBL2041010 |  |
IC50 | = | 2.0 | nM | 584.66 | COc1cc(N2C(=O)N(c3ccc(-c4ccc(C(=O)O)s4)cc3)C(=O)C23CCN(Cc2ncccc2C)CC3)ncn1 | Homo sapiens | CHEMBL2045988 | single protein format |