Q9H5J4 | ELOV6_HUMAN | Elongation of very long chain fatty acids protein 6 (ELOVL6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF01151 | ELO - GNS1/SUR4 family | 25~261 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL570571 |  |
IC50 | = | 2.6 | nM | 434.35 | O=C1Nc2ccc(-c3ccn[nH]3)cc2[C@](CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL571707 |  |
IC50 | = | 4.0 | nM | 434.35 | O=C1Nc2ccc(-c3ccn[nH]3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL490110 |  |
IC50 | = | 8.7 | nM | 509.53 | Cc1ccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)cc1 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL449121 |  |
IC50 | = | 8.9 | nM | 579.5 | Cc1[nH]n(-c2ccc(OC(F)(F)F)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL493642 |  |
IC50 | = | 10.0 | nM | 537.58 | Cc1[nH]n(-c2ccc(C(C)C)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL490750 |  |
IC50 | = | 12.0 | nM | 529.95 | Cc1[nH]n(-c2ccc(Cl)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL491949 |  |
IC50 | = | 14.0 | nM | 520.51 | Cc1[nH]n(-c2ccc(C#N)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL491944 |  |
IC50 | = | 17.0 | nM | 525.53 | COc1ccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)cc1 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL571698 |  |
IC50 | = | 22.0 | nM | 434.35 | O=C1Nc2ccc(-c3cn[nH]c3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL585922 |  |
IC50 | = | 26.0 | nM | 434.35 | O=C1Nc2ccc(-n3cccn3)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL572158 |  |
IC50 | = | 26.0 | nM | 402.73 | O=C1Nc2ccc(Cl)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL2307408 |  |
IC50 | = | 32.0 | nM | 412.56 | CC(C)c1ccc(NC(=O)N2[C@@H]3CC[C@H]2C[C@@H](S(=O)(=O)c2ccccc2)C3)cc1 | Homo sapiens | CHEMBL1031016 | assay format |
| CHEMBL570576 |  |
IC50 | = | 33.0 | nM | 417.75 | O=C(NCC1(C(F)(F)F)OC(=O)Nc2ccc(Cl)cc21)Nc1ccc(F)cc1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL582825 |  |
IC50 | = | 38.0 | nM | 398.77 | Cc1ccc(C(=O)NCC2(C(F)(F)F)OC(=O)Nc3ccc(Cl)cc32)cc1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL576264 |  |
IC50 | = | 39.0 | nM | 451.38 | O=C1Nc2ccc(N3CCCC3=O)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |
| CHEMBL521775 |  |
IC50 | = | 43.0 | nM | 525.53 | COc1cccc(-n2[nH]c(C)c(C3(C(F)(F)F)C(=O)N(c4ccccc4)C4=C3C(=O)CC(C)(C)C4)c2=O)c1 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL491921 |  |
IC50 | = | 44.0 | nM | 529.95 | Cc1[nH]n(-c2cccc(Cl)c2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL491948 |  |
IC50 | = | 44.0 | nM | 513.49 | Cc1[nH]n(-c2ccc(F)cc2)c(=O)c1C1(C(F)(F)F)C(=O)N(c2ccccc2)C2=C1C(=O)CC(C)(C)C2 | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL490760 |  |
IC50 | = | 58.0 | nM | 525.53 | COc1ccccc1-n1[nH]c(C)c(C2(C(F)(F)F)C(=O)N(c3ccccc3)C3=C2C(=O)CC(C)(C)C3)c1=O | Homo sapiens | CHEMBL1007916 | cell-based format |
| CHEMBL569399 |  |
IC50 | = | 67.0 | nM | 453.35 | O=C1Nc2ccc(N3CCOC3=O)cc2C(CNC(=O)c2ccc(F)cc2)(C(F)(F)F)O1 | Homo sapiens | CHEMBL1045787 | assay format |