Q9H5I1 | SUV92_HUMAN | Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00385 | Chromo - Chromo (CHRromatin Organisation MOdifier) domain | 47~94 | |
| PF00856 | SET - SET domain | 262~373 | |
| PF05033 | Pre-SET - Pre-SET motif | 148~242 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "Zn3Cys9 preSET domain-related" // Pre-SET ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4587289 |  |
IC50 | = | 1.77 | nM | 480.89 | COc1cc(OC)c(-c2cn3ccc(N4CCN(P(=O)(OC)OC)CC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4553838 |  |
IC50 | = | 1.78 | nM | 458.95 | COCC(=O)N1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1C | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4563069 |  |
IC50 | = | 1.88 | nM | 458.95 | COCC(=O)N1CCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)C(C)C1 | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4520078 |  |
IC50 | = | 1.97 | nM | 428.92 | COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)C(C)C4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4551654 |  |
IC50 | = | 2.0 | nM | 414.89 | COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)CC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4556599 |  |
IC50 | = | 2.07 | nM | 458.01 | COc1cc(OCCCN(C)C)c(-c2cn3ccc(N4CCCNCC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4556449 |  |
IC50 | = | 2.2 | nM | 535.07 | COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCN(S(=O)(=O)C5CC5)CC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4457187 |  |
IC50 | = | 2.71 | nM | 376.84 | COc1cc(OC)c(-c2cn3cc(NCCN)c(OC)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4534136 |  |
IC50 | = | 2.9 | nM | 551.02 | CCOP(=O)(CCN1CCCN(c2ccn3cc(-c4cc(Cl)c(OC)cc4OC)nc3c2)CC1)OCC | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4551056 |  |
IC50 | = | 3.0 | nM | 502.46 | COc1cc(OC)c(-c2cn3ccc(N4CCN(CCCN(C)C)CC4)cc3n2)cc1Br | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4547529 |  |
IC50 | = | 3.1 | nM | 438.75 | Br.COc1cc(OC)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4589569 |  |
IC50 | = | 3.27 | nM | 428.92 | COc1cc(OC)c(-c2cn3ccc(N4CCC(NC(C)=O)CC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4558804 |  |
IC50 | = | 3.33 | nM | 487.0 | COc1cc(OC)c(-c2cn3ccc(N4CCN(C(=O)OC(C)(C)C)C(C)C4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4514527 |  |
IC50 | = | 3.35 | nM | 431.92 | COc1cc(OC)c(-c2cn3cc(NCCN)c(N4CCOCC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4569911 |  |
IC50 | = | 3.49 | nM | 530.47 | COc1cc(OC)c(-c2cn3ccc(N4CCN(CCN5CCOCC5)CC4)cc3n2)cc1Br | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4536861 |  |
IC50 | = | 3.5 | nM | 428.92 | COc1cc(OC)c(-c2cn3ccc(N4CCN(C(C)=O)CC4C)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4557178 |  |
IC50 | = | 3.53 | nM | 515.06 | COc1cc(OC)c(-c2cn3ccc(N4CCN(CCC(=O)NCCN(C)C)CC4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4543316 |  |
IC50 | = | 3.71 | nM | 429.32 | Br.COc1cc(OC)c(-c2cn3ccc(N4CCCC4)cc3n2)cc1C#N | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4534069 |  |
IC50 | = | 3.81 | nM | 464.98 | COc1cc(OC)c(-c2cn3ccc(N4CCN(S(C)(=O)=O)C(C)C4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |
| CHEMBL4532138 |  |
IC50 | = | 3.81 | nM | 450.95 | COc1cc(OC)c(-c2cn3ccc(N4CCC(NS(C)(=O)=O)C4)cc3n2)cc1Cl | Homo sapiens | CHEMBL4477004 | single protein format |