Q9H4B4 | PLK3_HUMAN | Serine/threonine-protein kinase PLK3 (PLK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 64~314 | |
| PF00659 | POLO_box - POLO box duplicated region | 472~528 | |
| PF00659 | POLO_box - POLO box duplicated region | 569~633 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5435085 |  |
IC50 | = | 4.89 | nM | 561.69 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(-c4noc(CN5CCCNCC5)n4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL5361559 | single protein format |
| CHEMBL1208892 |  |
IC50 | = | 5.0 | nM | 524.53 | C[C@@H](Oc1cc(-n2cnc3cc(-c4ccnc(N)n4)ccc32)sc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL1212571 | single protein format |
| CHEMBL1945502 |  |
IC50 | = | 5.0 | nM | 468.03 | COc1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)cc1CCCN(C)C | Homo sapiens | CHEMBL1948344 | single protein format |
| CHEMBL1945500 |  |
IC50 | = | 5.0 | nM | 472.45 | CN(C)CCCc1cc(Cl)cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)c1 | Homo sapiens | CHEMBL1948344 | single protein format |
| CHEMBL1209842 |  |
IC50 | = | 6.0 | nM | 477.98 | C[C@@H](Oc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)sc1C(N)=O)c1ccccc1Cl | Homo sapiens | CHEMBL1212571 | single protein format |
| CHEMBL1209841 |  |
IC50 | = | 6.0 | nM | 511.53 | C[C@@H](Oc1cc(-n2cnc3cc(-c4cnn(C)c4)ccc32)sc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL1212571 | single protein format |
| CHEMBL1094477 |  |
IC50 | = | 6.0 | nM | 334.38 | Cc1ccccc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2 | Homo sapiens | CHEMBL1109143 | single protein format |
| CHEMBL222419 |  |
IC50 | = | 6.0 | nM | 457.94 | COc1cc2ncn(-c3cc(O[C@H](C)c4ccccc4Cl)c(C(N)=O)s3)c2cc1OC | Homo sapiens | CHEMBL960987 | cell-based format |
| CHEMBL4592698 |  |
IC50 | = | 6.04 | nM | 492.62 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCCC4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL4409682 | assay format |
| CHEMBL1945501 |  |
IC50 | = | 7.0 | nM | 455.99 | CN(C)CCCc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)ccc1F | Homo sapiens | CHEMBL1948344 | single protein format |
| CHEMBL5430344 |  |
IC50 | = | 7.56 | nM | 547.66 | CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(-c4noc(CN5CCNCC5)n4)cc3OC)nc2N1C1CCCC1 | Homo sapiens | CHEMBL5361559 | single protein format |
| CHEMBL1209605 |  |
IC50 | = | 8.0 | nM | 508.53 | C[C@@H](Oc1cc(-n2cnc3cc(-c4ccncc4)ccc32)sc1C(N)=O)c1ccccc1C(F)(F)F | Homo sapiens | CHEMBL1212571 | single protein format |
| CHEMBL1945801 |  |
IC50 | = | 9.0 | nM | 506.0 | CN(C)CCCc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)ccc1C(F)(F)F | Homo sapiens | CHEMBL1948344 | single protein format |
| CHEMBL514499 |  |
IC50 | = | 9.0 | nM | 477.46 | COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(C(N)=O)s3)c2cc1OC | Homo sapiens | CHEMBL960987 | cell-based format |
| CHEMBL514162 |  |
IC50 | = | 9.0 | nM | 443.91 | COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(C(N)=O)s3)c2cc1OC | Homo sapiens | CHEMBL960987 | cell-based format |
| CHEMBL1209674 |  |
IC50 | = | 10.0 | nM | 474.97 | C[C@@H](Oc1cc(-n2cnc3cc(-c4ccncc4)ccc32)sc1C(N)=O)c1ccccc1Cl | Homo sapiens | CHEMBL1212571 | single protein format |
| CHEMBL1095457 |  |
IC50 | = | 11.0 | nM | 349.4 | CNc1ccccc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2 | Homo sapiens | CHEMBL1109143 | single protein format |
| CHEMBL1945170 |  |
IC50 | = | 12.0 | nM | 438.0 | CN(C)CCCc1cccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2NC(=S)C3)c1 | Homo sapiens | CHEMBL1948344 | single protein format |
| CHEMBL1097022 |  |
IC50 | = | 13.0 | nM | 335.37 | Cn1nc(C(N)=O)c2c1-c1nc(Nc3ccccc3N)ncc1CC2 | Homo sapiens | CHEMBL1109143 | single protein format |
| CHEMBL1094135 |  |
IC50 | = | 13.0 | nM | 350.38 | COc1ccccc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2 | Homo sapiens | CHEMBL1109143 | single protein format |